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Oxidative stress and redox homeostasis have been shown to be involved at each stage of a malignant melanocyte transformation, called melanomagenesis, as well as during drug resistance.

Metastasizing melanoma can appear as gray-black or blue-black suggesting a robust eumelanin synthetic pathway. In addition, increased ROS in metastatic melanoma cells can prevent metastasis. Oxidative stress can impair cancer progression by suppressing protein translation .

Obesity is associated with melanoma initiation and progression, as it increases the risk of melanoma formation and favours melanoma growth, invasion and distant metastasis . Indeed, adipose tissue favours the proliferation and aggressiveness of melanoma cells through a direct dialogue, mediated by soluble factors and by exosomes, and through ...

Nov 1, 2005 · Thus, investigating normal melanocyte homeostasis helps us to better define how melanoma cells escape the microenvironment created by epidermal keratinocytes and how they develop new cellular partners in fibroblasts and endothelial …

Thus, investigating normal melanocyte homeostasis helps us to better define how melanoma cells escape the microenvironment created by epidermal keratinocytes and how they develop new cellular partners in fibroblasts and endothelial cells, which support their growth and invasion.

Aug 30, 2024 · Increasing evidence suggests a dual role of ROS in melanoma progression: excessive ROS production may enhance cellular growth and promote therapeutic resistance, but at the same time, it can also have cytotoxic effects on cancer cells, inducing their apoptosis.

Thus, investigating normal melanocyte homeostasis helps us to better define how melanoma cells escape the microenvironment created by epidermal keratinocytes and how they develop new cellular partners in fibroblasts and endothelial cells, which support their growth and invasion.

Mar 20, 2025 · Interferon-gamma (IFN-γ) is a cytokine produced mainly by immune cells and can affect cancer cells by modulating the activity of multiple signaling pathways, including the canonical Janus-activated kinase/signal transducer and activator of transcription (JAK/STAT) cascade. In melanoma, IFN-γ can exert both anticancer effects associated with cell-cycle …

Malignant tumors can putatively affect body homeostasis through the production of neurohormonal modulators entering the circulation, neurotransmitters activating receptors on nerve ending, or through priming circulating immune cells to regulate other organ functions.

Apr 1, 2023 · Malignant tumors can putatively affect body homeostasis through the production of neurohormonal modulators entering the circulation, neurotransmitters activating receptors on nerve endings, or the priming of circulating immune cells to regulate other organ functions.