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- To prevent protein misfolding, we can12:
- Target production
- Regulate chaperone operation
- Induce protein degradation
- Enhance extracellular clearance
- Counter proteotoxic stressors
Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.To fix misfolded proteins, we either need to target production, regulate chaperone operation, induce protein degradation, enhance extracellular clearance, or counter proteotoxic stressors.mybiohack.com/blog/protein-misfolding-proteopathyThe trick is finding the right balance between eliminating bad proteins and salvaging what’s fixable. “The cell needs to find a quality control sweet spot where it degrades the misfolded proteins to keep them from accumulating and being toxic but isn’t too zealous in degrading everything—including proteins that can still function,” Frydman says.www.futurity.org/misfolded-proteins-1927772/ - People also ask
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Mar 29, 2020 · To fix misfolded proteins, we either need to target production, regulate chaperone operation, induce protein degradation, enhance extracellular clearance, or counter proteotoxic stressors. Avoid: Stressors …
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