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- To prevent protein misfolding, we can12:
- Target production
- Regulate chaperone operation
- Induce protein degradation
- Enhance extracellular clearance
- Counter proteotoxic stressors
Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.To fix misfolded proteins, we either need to target production, regulate chaperone operation, induce protein degradation, enhance extracellular clearance, or counter proteotoxic stressors.mybiohack.com/blog/protein-misfolding-proteopathyThe trick is finding the right balance between eliminating bad proteins and salvaging what’s fixable. “The cell needs to find a quality control sweet spot where it degrades the misfolded proteins to keep them from accumulating and being toxic but isn’t too zealous in degrading everything—including proteins that can still function,” Frydman says.www.futurity.org/misfolded-proteins-1927772/ - People also ask
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Mar 29, 2020 · To fix misfolded proteins, we either need to target production, regulate chaperone operation, induce protein degradation, enhance extracellular clearance, or counter proteotoxic stressors. Avoid: Stressors …
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Dec 1, 2017 · This review aims to highlight the fundamental mechanism of protein misfolding leading to protein aggregation and associated diseases. It also aims to anticipate novel …
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Jul 10, 2020 · Here we will review the most relevant of these accomplishments in order to draw some lessons which may guide research on other protein misfolding diseases for which …
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Direct visualization and profiling of protein misfolding and ...
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