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Genomic and geographical structure of human cytomegalovirus
Human cytomegalovirus (CMV) has infected humans since the origin of our species and currently infects most of the world’s population. Variability between CMV genomes is the highest of any human herpesvirus, yet large portions of the genome are conserved.
See results only from pmc.ncbi.nlm.nih.govAtomic structure of the hum…
Here we report a HCMV atomic structure consisting of the herpesvirus-conserved …
Cytomegalovirus - StatPearl…
Human cytomegalovirus infections commonly are associated with the …
Human cytomegalovirus gen…
Human cytomegalovirus (HCMV) contains a large and complex E-type genome. …
Genomic and Functional Ch…
The complete genome of human cytomegalovirus (HCMV) was elucidated …
Human Cytomegalovirus- An Overview - Microbe Notes
- Figure: Structure of Human Cytomegalo Virus, Source: Dr. Marko Reschke, Marburg, Germany 1. Cytomegalovirus is a member of the herpes virus family that falls under the beta herpes subfamily. 2. CMV is spherical in shape with icosahedral symmetry. 3. The icosahedral protein capsid with an average diameter of 100 nm consists of 162 hollow hexagonal a...
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- Studies of human cytomegalovirus structure
Structure of human cytomegalovirus virion reveals host tRNA …
Sep 17, 2021 · Here, cryo-EM reconstructions of human cytomegalovirus (HCMV) virions reveal host tRNAs associated with the virion’s capsid-bound tegument protein, pp150. tRNA …
Human Cytomegalovirus - microbewiki - Kenyon College
Feb 12, 2016 · The human cytomegalovirus structure consists of an outer lipid bilayer envelope, composed of various viral glycoproteins, followed by the tegument, a proteinaceous matrix, which holds double stranded linear DNA core in an icosahedral nucleocapsid.
Functional Profile of Human Cytomegalovirus Genes …
Sep 3, 2020 · The human cytomegalovirus (HCMV), whose linear double-stranded DNA genome is 235 ± 1.9 kbp in length, has the largest genome among human herpesviruses. It has an E-type genome structure consisting of two …
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Atomic structure of the human cytomegalovirus capsid with its …
Jun 6, 2017 · Here we report a HCMV atomic structure consisting of the herpesvirus-conserved capsid proteins MCP, Tri1, Tri2, and SCP and the HCMV-specific tegument protein …
Structural basis for genome packaging, retention, and …
Jul 27, 2021 · How the human cytomegalovirus (HCMV) genome—the largest among human herpesviruses—is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry ...
Crystal Structure of the Human Cytomegalovirus …
Oct 20, 2015 · Human cytomegalovirus (HCMV), a dsDNA, enveloped virus, is a ubiquitous pathogen that establishes lifelong latent infections and caused disease in persons with compromised immune systems, e.g., organ transplant …
Structure and Formation of the Cytomegalovirus Virion
Studies of the composition, organization, and formation of these particles have provided insight into the molecular mechanisms of virus assembly, leads for antiviral strategies, and …
Three-Dimensional Structure of the Human Cytomegalovirus …
Nov 1, 2007 · Human cytomegalovirus (HCMV) induces profound changes in infected cell morphology, including a large cytoplasmic inclusion that corresponds to the virion assembly …
Genomic and Functional Characteristics of Human …
The complete genome of human cytomegalovirus (HCMV) was elucidated almost 25 years ago using a traditional cloning and Sanger sequencing approach. Analysis of the genetic content of …
Cryo-electron microscopy structures of capsids and in situ portals …
Apr 11, 2023 · Here we present high-resolution structures of the A- and B-capsids and in-situ portals of human cytomegalovirus. We show that scaffolds bind to the hydrophobic cavities …
Atomic structure of the human cytomegalovirus capsid with its ... - Science
Jun 30, 2017 · A 3.9-Å structure of human cytomegalovirus. One of the 60 asymmetric units that make up HCMV’s 1320-Å-wide capsid is rendered above a colored face of the icosahedral shell.
Human cytomegalovirus tegument proteins (pp65, pp71, pp150, …
Jan 17, 2012 · Human cytomegalovirus structure and life cycle. HCMV has the prototypical herpesvirus virion structure (Figure 1) and the replication cycle has a well controlled cascade …
Prefusion structure of human cytomegalovirus glycoprotein B and …
Mar 5, 2021 · Human cytomegalovirus (HCMV) causes congenital disease with long-term morbidity. HCMV glycoprotein B (gB) transitions irreversibly from a metastable prefusion to a …
Structure of human cytomegalovirus virion reveals host tRNA …
Sep 17, 2021 · Using the sequence of the most abundant tRNA species, we built atomic models into the tRNA density (Fig. 1g, h, Supplementary Video 2). The atomic model consists of four leaflets—acceptor stem (1–8 and 65–71 nt), D-arm (9–26 nt), anticodon arm (27–43 nt), and T-arm (48–64 nt) (Fig. 1g, h).
Cytomegalovirus - StatPearls - NCBI Bookshelf
Aug 8, 2023 · Human cytomegalovirus infections commonly are associated with the salivary glands. CMV infection may be asymptomatic in healthy people, but they can be life-threatening in an immunocompromised patient. This activity …
Human cytomegalovirus (CMV; species Human betaherpesvirus 5) is a member of the Betaherpesvirinae that infects circa 66 to 90% of adults in any given country (1).
Functional single-cell genomics of human cytomegalovirus …
Oct 25, 2021 · Pooled and single-cell CRISPR screens provide a detailed map of human cytomegalovirus infection. Understanding how viral and host factors interact and how …
Human cytomegalovirus genomics and transcriptomics through
Jan 2, 2019 · The human cytomegalovirus (HCMV) genome was sequenced by hierarchical shotgun almost 30 years ago. Over these years, low and high passaged strains have been sequenced, improving, albeit still far from complete, the understanding of the coding potential, expression dynamics and diversity of wild-type HCMV strains.
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