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Apr 30, 2024 · Although DNA methylation can be measured in several ways, the epigenetics community has enthusiastically embraced the Illumina HumanMethylation450 (450k) array …

Dec 1, 2024 · To assist future researchers and practitioners interested in analyzing DNA methylation array data, we’ve curated a list of commonly referenced datasets, detailing their …

Feb 10, 2022 · To address these challenges, we developed the mammalian methylation array, a single custom array that measures up to 36k CpGs per species that are well conserved across …

Aug 27, 2013 · Advancements in high-throughput assessment of DNA methylation using microarrays or second-generation sequencing-based approaches have enabled the …

Jul 31, 2024 · DNA methylation (DNAm) was measured from DNA purified blood collected from NHANES participants during the 1999–2000 and 2001–2002 cycles. DNAm was measured …

Apr 11, 2023 · Our tool provides scientists with a free, quick, and easy all-in-one solution to perform a full DNA methylation array analysis from raw data to exploration and visualization of …

May 8, 2012 · Emerging research demonstrates that DNA methylation is responsible for cellular differentiation, and when measured in whole peripheral blood, serves to distinguish cancer …

Nov 19, 2024 · Differences in DNA methylation between samples can either be at a single CpG which is called a differentially methylated position (DMP), or at a regional level which is called …

DNA methylation in vertebrates is characterized by the addition of a methyl or hydroxymethyl group to the C5 position of cytosine, which occurs mainly in the context of CG dinucleotides. …

The Illumina Infinium Methylation microarray is based on the Illumina Infinium genotyping platform and queries individual CpG sites across the human genome by measuring the C/T ratio …

Dec 3, 2014 · In 2011, Illumina released the HumanMethylation450 bead array [1], also known as the 450k array. This array has enabled population-level studies of DNA methylation by …

This review surveys the current state of computational tools/algorithms for the analysis of microarray-based DNA methylation profiling datasets, focusing on key concepts underlying the …

Get an overview of the relationship between DNA methylation and specific elements of the mammalian genome. Methylation microarray technology is a proven approach to analyze DNA …

Apr 11, 2018 · Here we proposed a generalized framework for evaluating data analysis methods for Illumina 450K array. This framework considers the following steps towards a successful …

Feb 2, 2023 · Arrays provide a cost-effective platform for the analysis of human DNA methylation. ShinyÉPICo is an interactive, web-based, and graphical tool that allows the user to analyze …

Mar 14, 2025 · Here, Cilleros-Portet et al. present a large placental methylation database as a tool to explore the genetic burden that acts in prenatal stages, giving insight into neuropsychiatric …

4 days ago · Chemical modifications to DNA, such as methylation, regulate gene expression without altering the genetic code. These epigenetic changes influence development, aging, …

4 days ago · Background Adaptive Banded Event Alignment (ABEA) stands as a critical algorithmic component in sequence polishing and DNA methylation detection, employing …

The Infinium Methylation Assay provides quantitative array-based methylation measurement at the single-CpG-site level, offering high resolution for understanding epigenetic changes. …

Mar 7, 2025 · Prime editors (PEs) have emerged as transformative tools for precision genome engineering, yet their broader application remains constrained by incomplete understanding of …

Feb 21, 2025 · Aberrant genome-wide DNA methylation patterns is common in cancers. Understanding how these affect the transcriptome can provide insights into subtype specific …

1 day ago · Using longitudinal methylation profiling, we find these tumors upregulate bifurcated phenotypes regulating both DNA repair and inflammatory programs. These data are …

Their collective effects are particularly prevalent to numerous aspects of brain function, including energy production, DNA/RNA synthesis/repair, genomic and non-genomic methylation, and …