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  1. Deoxyribozyme - Wikipedia

    • Deoxyribozymes, also called DNA enzymes, DNAzymes, or catalytic DNA, are DNA oligonucleotides that are capable of performing a specific chemical reaction, often but not always catalytic. This is similar to the action of other biological enzymes, such as proteins or ribozymes (enzymes composed of RNA). However, in contrast to the abundance of protein enzymes … See more

    Types

    The most abundant class of deoxyribozymes are ribonucleases, which catalyze the cleavage of a ribonucleotide
    The … See more

    Methods

    Because there are no known naturally occurring deoxyribozymes, most known deoxyribozyme sequences have been discovered through a high-throughput in vitro selection technique, similar to SELEX. in vitro sele… See more

    Applications

    Although RNA enzymes were discovered before DNA enzymes, the latter have some distinct advantages. DNA is more cost-effective, and DNA can be made with longer sequence length and can be made with higher … See more

    See also

    • Aptamer – Oligonucleotide or peptide molecules that bind specific targets
    • Ribozyme – Type of RNA molecules
    • Systematic evolution of ligands by exponential enrichment (SELEX) – Technique … See more

    External links

    • Deoxyribozyme at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more

     
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  2. The dynamic world of the 8–17 DNAzyme - Nature

    Jun 17, 2024 · High-precision DNA-based biocatalysts, known as DNA enzymes or DNAzymes, are experiencing a revival in biotechnological, analytical, and therapeutical applications.

     
  3. A biologically stable DNAzyme that efficiently …

    Mar 25, 2021 · Here we report a re-engineered version of the classic 10–23 DNAzyme that mediates persistent gene-silencing activity in cultured mammalian cells and simultaneously resists nuclease digestion.

  4. DNA Catalysis: The Chemical Repertoire of …

    Deoxyribozymes or DNAzymes are single-stranded catalytic DNA molecules that are obtained by combinatorial in vitro selection methods.

  5. Designing in vivo active DNAzymes | Nature Chemistry

  6. DNAmoreDB, a database of DNAzymes - PMC

  7. People also ask
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  9. DNAzymes: from creation in vitro to application in vivo

  10. DNAzymes: Synthetic Enzymes Made of DNA | SpringerLink

  11. Evidence of a General Acid/Base Catalysis Mechanism in the 8 …

  12. Therapeutic DNAzymes: From Structure Design to …

    Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their prosperous gene regulation capability. The efficacy of DNAzymes against many types of diseases has been extensively studied for over two …

  13. DNAzymes – How Active DNA Biocatalysts That Destroy

  14. The 8-17 DNAzyme can operate in a single active structure …

  15. Single–Molecule Study of DNAzyme Reveals Its Intrinsic …

  16. DNAzymes: Expanding the Potential of Nucleic Acid Therapeutics

  17. Unraveling the Kinetics of the 10–23 RNA-Cleaving DNAzyme

  18. DNAzymes: How active DNA molecules with therapeutic potential …

  19. Biosensing with DNAzymes - PMC

  20. Multivalent DNAzyme nanomachine generated by exonuclease III …