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WEBOct 23, 2018 · Glutamine synthesis by the GS depends on glutamate availability. Glutamate, in turn, is synthesized from 2-oxoglutarate NH 4, through the action of the glutamate dehydrogenase, or even from the catabolism of other amino acids, such as …
- Author: Vinicius Cruzat, Marcelo Macedo Rogero, Kevin Noel Keane, Rui Curi, Philip Newsholme
- Publish Year: 2018
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Glutamine synthetase (GS) (EC 6.3.1.2) is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine:
Glutamate + ATP + NH3 → Glutamine + ADP + phosphate
Glutamine synthetase uses ammonia produced by nitrate reduction, amino acid degradation, …Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 9 mins
Glutamine is produced industrially using mutants of Brevibacterium flavum, which gives ca. 40 g/L in 2 days using glucose as a carbon source.
Glutamine synthesis from glutamate and ammonia is catalyzed by the enzyme glutamine synthetase. The majority of glutamine production occurs in muscle tissue, accounting for about 90% of all glutamine synthesized. Glutamine is also released, in small amounts, by the lungs and brain. Alt…Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 8 mins
WEBSep 17, 2020 · In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why …
WEBGlutamine synthetase is a cytosolic enzyme that catalyzes the synthesis of glutamine from glutamate and free NH 4 + in an ATP-dependent reaction (Fig. 1). The human gene …
WEBAug 3, 2018 · Glutamine synthetase (GS) is an enzyme that regulates nitrogen metabolism and synthesizes glutamine via glutamate, ATP, and ammonia. GS is a homo-oligomeric …
WEBFeb 19, 2018 · Glutamine synthetase (GS) is the adenosine triphosphate (ATP)-dependent enzyme that catalyses the synthesis of glutamine by condensing ammonium to …
WEBAug 1, 2021 · Similar to the reactions in glycolysis, glutaminolysis involves a series of biochemical reactions participating in energy generation and nucleotide biosynthesis, …
WEBAug 29, 2018 · Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible...
WEBSep 17, 2020 · In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why …
Glutamine Synthetase - Chemistry LibreTexts
WEBMay 1, 2022 · Glutamine synthetase (GS) is an enzyme that is responsible for catalyzing the reaction that synthesizes glutamine from glutamate and ammonia. Additionally, GS catalyzes the reverse …
Advances in the functional study of glutamine ... - ScienceDirect
WEBAug 1, 2022 · Plant glutamine synthetase (GS, EC6.3.1.2) catalyzes the synthesis of glutamine from glutamate and ammonium ions and acts as a key enzyme in the nitrogen …
Glutamine Metabolism | Cell Signaling Technology
WEBIn the cytosol, glutamine donates its γ (amide) nitrogen for the synthesis of nucleotides and hexosamines, producing glutamate in the process. Cytosolic glutamate is critical for …
Differences in regulation mechanisms of glutamine synthetases
WEBJan 19, 2024 · Glutamine synthetases (GS) catalyze the ATP-dependent ammonium assimilation, the initial step of nitrogen acquisition that must be under tight control to fit …
Glutamine: What It Is, Benefits & Side Effects - Cleveland Clinic
WEBMar 8, 2024 · Policy. What does glutamine do for your body? Glutamine is an essential protein building block. It also helps make other amino acids and removes waste …
Monitoring and modelling the glutamine metabolic pathway: a …
WEBJul 23, 2023 · Analysis of the glutamine metabolic pathway has taken a special place in metabolomics research in recent years, given its important role in cell biosynthesis and …
Glutamine: Metabolism and Immune Function, Supplementation …
WEBOct 23, 2018 · Glutamine release to the circulation and availability is mainly controlled by key metabolic organs, such as the gut, liver, and skeletal muscles.
Amino acids regulating skeletal muscle metabolism: mechanisms …
WEBJul 2, 2024 · Collectively, glutamine may increase MPS and reduce MPB through various potential mechanisms (Fig. 1), including the activation of AKT signaling pathways, …
Pyruvate carboxylase and cancer progression | Cancer
WEBApr 30, 2021 · Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish …
Hepatic glutamine synthetase controls - Nature
WEBOct 24, 2022 · Glutamine synthetase (GS) activity is conserved from prokaryotes to humans, where the ATP-dependent production of glutamine from glutamate and …
Targeting YAP Activity and Glutamine Metabolism Cooperatively …
WEB1 day ago · Cancer cells use multiple mechanisms to evade the effects of glutamine metabolism inhibitors. The pathways that govern responses to alterations in glutamine …
Glutamine - an overview | ScienceDirect Topics
WEBGlutamine is an obligatory precursor of glutamate and GABA; it is produced from glutamate by glutamine synthetase, expressed solely in astrocytes and then exported by Na+ …
The Many Roles of Glutamate in Metabolism - PMC - National …
WEBGlutamate biosynthetic pathways. Glutamate is made from the citric acid cycle intermediate 2-oxoglutarate (2-OG) by reductive amination with either ammonium or glutamine as the …
Targeting YAP Activity and Glutamine Metabolism Cooperatively ...
WEB1 day ago · Abstract. Cancer cells use multiple mechanisms to evade the effects of glutamine metabolism inhibitors. The pathways that govern responses to alterations in …
Targeting the glutamine-arginine-proline metabolism axis in cancer
WEB5 days ago · Glutamine addiction of cancer cells. Metabolic abnormalities are an important feature of cancers Citation 1.Rapidly proliferating cancer cells rely mainly on glutamine …
Glutamine synthetase activity fuels nucleotide biosynthesis and ...
WEBNov 23, 2015 · Abstract. L -Glutamine (Gln) functions physiologically to balance the carbon and nitrogen requirements of tissues. It has been proposed that in cancer cells …
The Fate of Glutamine in Human Metabolism. The Interplay with …
WEBApr 26, 2019 · Our analysis shows that glutamine can supply carbon sources for cell energy production and can be used as carbon and nitrogen sources to synthesize essential …
A pathway map of glutamate metabolism - PMC - National Center …
WEBDec 3, 2015 · Glutamate is a non-essential amino acid that can be synthesized in the body through distinct metabolic pathways. It is an excitatory neurotransmitter in the central …
Glutathione synthesis in the mouse liver supports lipid ... - Nature
WEBJul 21, 2024 · The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many …
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