Glutamine Synthetase - Search
Open links in new tab
  1. All images
    All images
    Structure

    Glutamine synthetase can be composed of 8, 10, or 12 identical subunits separated into two face-to-face rings. … See more

    Wikipedia
    https://en.wikipedia.org/wiki/Glutamine_synthetase

    Glutamine synthetase - Wikipedia

    • Glutamine synthetase (GS) (EC 6.3.1.2) is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH3 → Glutamine + ADP + phosphate Glutamine synthetase uses ammonia produced by nitrate reduction, amino acid degradation, and photorespiration. T… See more

    Mechanism

    GS catalyzes the ATP-dependent condensation of glutamate with ammonia to yield glutamine. The hydrolysis of ATP drives the first step of a two-part, concerted mechanism. ATP phosphorylates glutamate to form AD… See more

    Biological function

    GS is present predominantly in the brain, kidneys, and liver. GS in the brain participates in the metabolic regulation of glutamate, the detoxification of brain ammonia, the assimilation of ammonia, recyclizatio… See more

    Classes

    There seem to be three different classes of GS:
    • Class I enzymes (GSI) are specific to prokaryotes, and are oligomers of 12 identical subunits. The activity of GSI-type enzyme is … See more

    Regulation and inhibition

    GS is subject to reversible covalent modification. Tyr of all 12 subunits can undergo adenylylation or deadenylylation by adenylyl transferase (AT), a bifunctional regulatory enzyme. Adenylylation is a post-translationa… See more

    External links

    • InterPro entry
    • RCSB PDB molecule of the month
    • PDBe-KB provides an overview of all the structure information available in the PDB for human glutamine synthetase… See more

    Wikipedia text under CC-BY-SA license
    Feedback
    Table of Contents
    Structure
    Mechanism
    Biological function
    Classes
    Regulation and inhibition
    External links
     

  1. Bokep

    https://viralbokep.com/viral+bokep+terbaru+2021&FORM=R5FD6

    Aug 11, 2021 Â· Bokep Indo Skandal Baru 2021 Lagi Viral - Nonton Bokep hanya Itubokep.shop Bokep Indo Skandal Baru 2021 Lagi Viral, Situs nonton film bokep terbaru dan terlengkap 2020 Bokep ABG Indonesia Bokep Viral 2020, Nonton Video Bokep, Film Bokep, Video Bokep Terbaru, Video Bokep Indo, Video Bokep Barat, Video Bokep Jepang, Video Bokep, Streaming Video …

    Kizdar net | Kizdar net | Кыздар Нет

  2. Glutamine synthetase (GS) (EC 6.3.1.2) is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH 3 → Glutamine + ADP + phosphate

    Glutamine synthetase - Wikipedia

    en.wikipedia.org/wiki/Glutamine_synthetase
    The enzyme glutamine synthetase is a key enzyme controlling the use of nitrogen inside cells. Glutamine, as well as being used to build proteins, delivers nitrogen atoms to enzymes that build nitrogen-rich molecules, such as DNA bases and amino acids. So, glutamine synthetase, the enzyme that builds glutamine, must be carefully controlled.

    Molecule of the Month: Glutamine Synth…

    pdb101.rcsb.org/motm/30
    Glutamine synthetase (GS) is an essential enzyme in the cellular nitrogen metabolism and has been found to play a role in both ammonia assimilation and glutamine byosynthesis. It is the only enzyme capable of glutamine synthesis and is required for the two step process synthesizing glutamate to glutamine.

    Glutamine synthetase - Proteopedia, lif…

    proteopedia.org/wiki/index.php/Glutamine_syntheta…
    Glutamine synthetase (GS) is the adenosine triphosphate (ATP)-dependent enzyme that catalyses the synthesis of glutamine by condensing ammonium to glutamate.

    Glutamine Synthetase: Localization Dict…

    www.mdpi.com/2073-4425/9/2/108
     
  3. People also ask
    What is the function of glutamine synthetase?
    [ 2 ] Glutamine synthetase (GS) (EC 6.3.1.2) [ 3 ] is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH 3 → Glutamine + ADP + phosphate

    Glutamine synthetase - Wikipedia

    en.wikipedia.org
    What are the benefits of glutamine?

    Cassia D Muller

    Bachelor in Nutrition · 2 years of exp

    Glutamine is naturally produced by the body, but in some cases, especially those with intestinal inflammation, the amount produced is not enough and supplementation can be very beneficial. It has the function of feeding the good bacteria in the intestine, and the mucus barrier that is formed around the villi of the intestine, improving immunity and nutrient absorption. Patients with irritable bowel syndrome, who have food intolerances or suffer from diarrhea are the most benefited by supplementation.
    Q&A: Glutamine
    bing.com
    How is glutamine synthetase produced?
    Glutamine synthetase uses ammonia produced by nitrate reduction, amino acid degradation, and photorespiration. [ 4 ] The amide group of glutamate is a nitrogen source for the synthesis of glutamine pathway metabolites. [ 5 ] Other reactions may take place via GS.

    Glutamine synthetase - Wikipedia

    en.wikipedia.org
    How is glutamine synthetase regulated?
    Glutamine synthetase has been reported be regulated by a number of covalent modifications (acylation, nitration, phosphorylation and succinylation) in specific cells under specific, often pathological, conditions (Gorg et al., 2007; Huyghe et al., 2019; Zhu et al., 2019).

    Glutamine Synthetase - an overview | ScienceDirect Topics

    sciencedirect.com
    What is the structure of bacterial glutamine synthetase?
    Proposed two step mechanism for the synthesis of glutamate and ammonia to yield glutamine. The general structure of bacterial GS is a dodecamer formed from two face-to-face hexameric rings of subunits. There are twelve active sites, one in each monomer. 5 Figure 3 below illustrates the structure of bacterial glutamine synthetase.

    Glutamine Synthetase - Chemistry LibreTexts

    chem.libretexts.org
    Does glutamine synthetase produce a methylated glutamine analog?
    Glutamine synthetase (GS) activity is conserved from prokaryotes to humans, where the ATP-dependent production of glutamine from glutamate and ammonia is essential for neurotransmission and ammonia detoxification. Here, we show that mammalian GS uses glutamate and methylamine to produce a methylated glutamine analog, N5 -methylglutamine.

    Hepatic glutamine synthetase controls - Nature

    nature.com
    Feedback
     
  4. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5852604

    Glutamine Synthetase: Localization Dictates Outcome - PMC

     
  5. ScienceDirect
    https://www.sciencedirect.com/.../glutamine-synthetase

    Glutamine Synthetase - an overview | ScienceDirect Topics

  6. Nature
    https://www.nature.com/articles/s12276-020-00504-8

    Glutamine reliance in cell metabolism | Experimental ... - Nature

  7. Nature
    https://www.nature.com/articles/s41586-018-0466-7

    Role of glutamine synthetase in angiogenesis beyond ... - Nature

  8. Nature
    https://www.nature.com/articles/s41598-018-30191-5

    Structural Analysis of Glutamine Synthetase from - Nature

  9. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/...

    Advances in the functional study of glutamine synthetase in plant ...

  10. Chemistry LibreTexts
    https://chem.libretexts.org/Courses/Saint_Marys...

    Glutamine Synthetase - Chemistry LibreTexts

  11. PubMed
    https://pubmed.ncbi.nlm.nih.gov/27885636

    Glutamine Synthetase: Role in Neurological Disorders

  12. PubMed
    https://pubmed.ncbi.nlm.nih.gov/24256247

    Astrocyte glutamine synthetase: pivotal in health and disease

  13. PDB-101
    https://pdb101.rcsb.org/motm/30

    Molecule of the Month: Glutamine Synthetase - RCSB: PDB-101

  14. mhmedical.com
    https://ommbid.mhmedical.com/content.aspx?bookid=...

    Glutaminase and Glutamine Synthetase ... - McGraw Hill Medical

  15. Nature
    https://www.nature.com/articles/s41598-017-01071-1

    The role of glutamine synthetase isozymes in enhancing ... - Nature

  16. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC4753154

    The Many Roles of Glutamate in Metabolism - PMC

  17. Amino Acids
    https://aminoacidsguide.com/Gln.html

    Glutamine - Gln - structure, properties, function, benefits

  18. GeneCards
    https://www.genecards.org/cgi-bin/carddisp.pl?gene=GLUL

    GLUL Gene - GeneCards | GLNA Protein | GLNA Antibody

  19. Nature
    https://www.nature.com/articles/s41589-022-01154-9

    Hepatic glutamine synthetase controls N 5 -methylglutamine in

  20. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7915753

    Glutamine Synthetase as a Therapeutic Target for Cancer …

  21. PubMed
    https://pubmed.ncbi.nlm.nih.gov/18691144

    Inhibitors of glutamine synthetase and their potential ... - PubMed

  22. Nature
    https://www.nature.com/articles/s42003-023-05726-w

    Differences in regulation mechanisms of glutamine synthetases …