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Aug 3, 2023 · HBV encodes a regulatory protein, HBx, which activates transcription and replication of HBV genome organized as covalently closed circular (ccc) DNA …

Jan 3, 2025 · Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution …

Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a chromatinized …

Mar 7, 2025 · Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome Wei Liu, Wei Liu State Key Laboratory of Molecular Oncology, MOE Key Laboratory of Protein …

Sep 25, 2019 · HBV cccDNA accumulates in nucleus as a chromatin-like cccDNA minichromosome assembled by histones and non-histones. However, the underlying …

After uncoating, rcDNA in the HBV nucleocapsid is translocated into the nucleus and converted into cccDNA minichromosome. The detailed molecular mechanisms of nucleocapsid …

Jul 25, 2020 · Understanding the mechanisms of epigenetic regulation in cccDNA minichromosome is crucial to develop new therapy on cccDNA, an attractive target for HBV cure.

The HBV replicative intermediate cccDNA (covalently closed circular HBV DNA), which serves as a template for the transcription of all viral transcripts including the pregenomic RNA (pgRNA), …

Feb 20, 2025 · Chronic hepatitis B virus (HBV) infection is an incurable pathogen responsible for causing liver disease and hepatocellular carcinoma. During the genesis of infection, HBV …

Mar 13, 2024 · Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a …

Nov 24, 2009 · Here we investigated the recruitment of HBx onto the HBV minichromosome and its ability to regulate the epigenetic control of cccDNA function in HBV replicating cells.

Jul 24, 2024 · The covalently closed circular DNA (cccDNA) of the hepatitis B virus (HBV) is organized as a minichromosome structure in the nucleus of infected hepatocytes and …

Mar 16, 2001 · The replicative intermediate of hepatitis B virus (HBV), the covalently closed, circular DNA, is organized into minichromosomes in the nucleus of the infected cell by histone …

HBV cccDNA minichromosomes in distinct epigenetic transcriptional states showed a similar reduction rate during cell division but significantly differed in their accessibility and vulnerability …

Sep 7, 2020 · IFN-α epigenetically regulates the HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA. Our findings provide …

Mar 8, 2025 · They successfully generated the HBV minichromosome for the first time, using their capabilities in reconstituting viral DNA in complex with human histones — which are proteins …

Feb 20, 2025 · In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, research led by MSK, Weill Cornell …

Jan 3, 2025 · Here, for the first time, we demonstrated that HBV exploits MRN complex to assemble its minichromosome. This study shed lights on the biogenesis of HBV cccDNA, …

Jan 1, 2022 · Altogether, we show a crucial role for HIRA in the interplay between HBV genome and host cellular machinery to ensure the formation and active transcription of the viral …

Nov 24, 2009 · HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones …

Upon hepatitis B virus (HBV) infection, partially double-stranded viral DNA converts into a covalently closed circular chromatinized episomal structure (cccDNA). This form represents …

2 days ago · 乙型肝炎病毒（HBV）感染是全球范围内严重的公共卫生挑战。长期感染可引发慢性肝炎、肝纤维化、肝硬化，最终导致肝细胞癌（HCC）。HBV侵染宿主细胞后，其基因组进 …

Apr 15, 2024 · Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a …

2 days ago · 2025年3月7日，清华大学基础医学院李海涛课题组在Protein & Cell杂志上发表了题为Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome（HBx构象变化驱 …

Altogether, we show a crucial role for HIRA in the interplay between HBV genome and host cellular machinery to ensure the formation and active transcription of the viral …