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Aug 3, 2023 · HBV encodes a regulatory protein, HBx, which activates transcription and replication of HBV genome organized as covalently closed circular (ccc) DNA …

Mar 13, 2024 · Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a …

After uncoating, rcDNA in the HBV nucleocapsid is translocated into the nucleus and converted into cccDNA minichromosome. The detailed molecular mechanisms of nucleocapsid …

The HBV replicative intermediate cccDNA (covalently closed circular HBV DNA), which serves as a template for the transcription of all viral transcripts including the pregenomic RNA (pgRNA), …

Sep 25, 2019 · HBV cccDNA accumulates in nucleus as a chromatin-like cccDNA minichromosome assembled by histones and non-histones. However, the underlying …

Feb 20, 2025 · During the genesis of infection, HBV establishes an independent minichromosome consisting of the viral covalently closed circular DNA (cccDNA) genome and host histones. …

Jul 25, 2020 · Understanding the mechanisms of epigenetic regulation in cccDNA minichromosome is crucial to develop new therapy on cccDNA, an attractive target for HBV cure.

Jan 3, 2025 · Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution …

Mar 7, 2025 · Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome Wei Liu, Wei Liu State Key Laboratory of Molecular Oncology, MOE Key Laboratory of Protein …

Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a chromatinized …

Mar 16, 2001 · The replicative intermediate of hepatitis B virus (HBV), the covalently closed, circular DNA, is organized into minichromosomes in the nucleus of the infected cell by histone …

Sep 7, 2020 · IFN-α epigenetically regulates the HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA. Our findings provide …

Feb 20, 2025 · In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, research led by MSK, Weill Cornell …

Apr 15, 2024 · Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a …

May 26, 2022 · Altogether, we show a crucial role for HIRA in the interplay between HBV genome and host cellular machinery to ensure the formation and active transcription of the viral …

Mar 8, 2025 · They successfully generated the HBV minichromosome for the first time, using their capabilities in reconstituting viral DNA in complex with human histones — which are proteins …

HBV cccDNA minichromosomes in distinct epigenetic transcriptional states showed a similar reduction rate during cell division but significantly differed in their accessibility and vulnerability …

3 days ago · 乙型肝炎病毒（HBV）感染是全球范围内严重的公共卫生挑战。长期感染可引发慢性肝炎、肝纤维化、肝硬化，最终导致肝细胞癌（HCC）。HBV侵染宿主细胞后，其基因组进 …

Altogether, we show a crucial role for HIRA in the interplay between HBV genome and host cellular machinery to ensure the formation and active transcription of the viral …

3 days ago · 2025年3月7日，清华大学基础医学院李海涛课题组在Protein & Cell杂志上发表了题为Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome（HBx构象变化驱 …

Upon hepatitis B virus (HBV) infection, partially double-stranded viral DNA converts into a covalently closed circular chromatinized episomal structure (cccDNA). This form represents …

Feb 16, 2025 · During the genesis of infection, HBV establishes an independent minichromosome consisting of the viral covalently closed circular DNA (cccDNA) genome and host histones. …