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- Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a chromatinized minichromosome and is the major template for HBV gene transcription.www.mdpi.com/1999-4915/16/4/609
Structural organization of the hepatitis B virus minichromosome
Mar 16, 2001 · The replicative intermediate of hepatitis B virus (HBV), the covalently closed, circular DNA, is organized into minichromosomes in the nucleus of the infected cell by histone and non-histone proteins. In this study we investigated the architecture of the HBV …
- Author: C T Bock, S Schwinn, S Locarnini, J Fyfe, M P Manns, C Trautwein, H Zentgraf
- Publish Year: 2001
See results only from pubmed.ncbi.nlm.nih.govEpigenetic Regulation of He…
After uncoating, rcDNA in the HBV nucleocapsid is translocated into the …
Nuclear HBx binds the HBV …
The HBV replicative intermediate cccDNA (covalently closed circular HBV DNA), …
Mechanisms of Hepatitis B …
Central to HBV persistence is the formation of covalently closed circular DNA …
HIRA Supports Hepatitis B …
Altogether, we show a crucial role for HIRA in the interplay between HBV genome …
HAT1 signaling confers to as…
HBV cccDNA accumulates in nucleus as a chromatin-like cccDNA …
Mechanisms of Hepatitis B …
Central to HBV persistence is the formation of covalently closed circular DNA …
Molecular insights into Spindlin1-HBx interplay and its impact on …
Aug 3, 2023 · HBV encodes a regulatory protein, HBx, which activates transcription and replication of HBV genome organized as covalently closed circular (ccc) DNA …
Mechanisms of Hepatitis B Virus cccDNA and Minichromosome …
Mar 13, 2024 · Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a …
- Studies of HBV Minichromosome
Epigenetic Regulation of Hepatitis B Virus Covalently Closed …
After uncoating, rcDNA in the HBV nucleocapsid is translocated into the nucleus and converted into cccDNA minichromosome. The detailed molecular mechanisms of nucleocapsid …
Nuclear HBx binds the HBV minichromosome and modifies the …
The HBV replicative intermediate cccDNA (covalently closed circular HBV DNA), which serves as a template for the transcription of all viral transcripts including the pregenomic RNA (pgRNA), …
HAT1 signaling confers to assembly and epigenetic regulation of …
Sep 25, 2019 · HBV cccDNA accumulates in nucleus as a chromatin-like cccDNA minichromosome assembled by histones and non-histones. However, the underlying …
A nucleosome switch primes hepatitis B virus infection - Cell Press
Feb 20, 2025 · During the genesis of infection, HBV establishes an independent minichromosome consisting of the viral covalently closed circular DNA (cccDNA) genome and host histones. …
Epigenetic regulation of covalently closed circular DNA …
Jul 25, 2020 · Understanding the mechanisms of epigenetic regulation in cccDNA minichromosome is crucial to develop new therapy on cccDNA, an attractive target for HBV cure.
Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its …
Jan 3, 2025 · Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution …
Unfolding HBx for an epigenetic switch of HBV cccDNA …
Mar 7, 2025 · Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome Wei Liu, Wei Liu State Key Laboratory of Molecular Oncology, MOE Key Laboratory of Protein …
Nuclear HBx binds the HBV minichromosome and …
Nov 24, 2009 · Here we investigated the recruitment of HBx onto the HBV minichromosome and its ability to regulate the epigenetic control of cccDNA function in HBV replicating cells.
Mechanisms of Hepatitis B Virus cccDNA and Minichromosome …
Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a chromatinized …
Structural organization of the hepatitis B virus minichromosome
Mar 16, 2001 · The replicative intermediate of hepatitis B virus (HBV), the covalently closed, circular DNA, is organized into minichromosomes in the nucleus of the infected cell by histone …
IFN-α confers epigenetic regulation of HBV cccDNA …
Sep 7, 2020 · IFN-α epigenetically regulates the HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA. Our findings provide …
Digging Into a Decades-Old Hepatitis B Mystery Suggests a New …
Feb 20, 2025 · In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, research led by MSK, Weill Cornell …
Mechanisms of Hepatitis B Virus cccDNA and Minichromosome …
Apr 15, 2024 · Central to HBV persistence is the formation of covalently closed circular DNA (cccDNA) from the incoming relaxed circular DNA (rcDNA) genome. cccDNA persists as a …
HIRA Supports Hepatitis B Virus Minichromosome Establishment …
May 26, 2022 · Altogether, we show a crucial role for HIRA in the interplay between HBV genome and host cellular machinery to ensure the formation and active transcription of the viral …
Decades-Old Hepatitis B Mystery Solved - SciTechDaily
Mar 8, 2025 · They successfully generated the HBV minichromosome for the first time, using their capabilities in reconstituting viral DNA in complex with human histones — which are proteins …
HBV covalently closed circular DNA minichromosomes in distinct ...
HBV cccDNA minichromosomes in distinct epigenetic transcriptional states showed a similar reduction rate during cell division but significantly differed in their accessibility and vulnerability …
清华大学基础医学院李海涛课题组阐述HBx通过双态构象切换调控 …
3 days ago · 乙型肝炎病毒(HBV)感染是全球范围内严重的公共卫生挑战。长期感染可引发慢性肝炎、肝纤维化、肝硬化,最终导致肝细胞癌(HCC)。HBV侵染宿主细胞后,其基因组进 …
HIRA Supports Hepatitis B Virus Minichromosome Establishment …
Altogether, we show a crucial role for HIRA in the interplay between HBV genome and host cellular machinery to ensure the formation and active transcription of the viral …
【科技前沿】Protein & Cell|李海涛团队阐述HBx通过双态构象切 …
3 days ago · 2025年3月7日,清华大学基础医学院李海涛课题组在Protein & Cell杂志上发表了题为Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome(HBx构象变化驱 …
HIRA Supports Hepatitis B Virus Minichromosome Establishment …
Upon hepatitis B virus (HBV) infection, partially double-stranded viral DNA converts into a covalently closed circular chromatinized episomal structure (cccDNA). This form represents …
A nucleosome switch primes hepatitis B virus infection
Feb 16, 2025 · During the genesis of infection, HBV establishes an independent minichromosome consisting of the viral covalently closed circular DNA (cccDNA) genome and host histones. …
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