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First Phase 3 TREMFYA® (guselkumab) Data in Inflammatory …
May 9, 2023 · The QUASAR study is designed to answer scientific questions pertaining to the efficacy and safety of guselkumab in the treatment of moderately to severely active UC. …
Clinical Trial Design | TREMFYA® (guselkumab) HCP
TREMFYA ® (guselkumab) is indicated for the treatment of adults with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy. TREMFYA ® is indicated for the treatment of adults with active …
Guselkumab in patients with moderately to severely …
Jan 4, 2025 · The results of the QUASAR phase 3 studies show that guselkumab is effective for induction and maintenance treatment in patients with moderately to severely active ulcerative colitis.
TREMFYA® (guselkumab) QUASAR Maintenance Study in UC …
May 20, 2024 · QUASAR is a randomized, double-blind, placebo-controlled, parallel group, multicenter, seamless Phase 2b/3 program designed to evaluate the efficacy and safety of …
Guselkumab in Patients With Moderately to Severely Active …
Sep 3, 2023 · Background & aims: The QUASAR Phase 2b Induction Study evaluated the efficacy and safety of guselkumab, an interleukin-23p19 subunit antagonist, in patients with moderately …
TREMFYA® (guselkumab) receives U.S. FDA approval for adults …
The QUASAR results reinforced the well-established safety profile of TREMFYA ® including in the treatment of patients with UC. This FDA approval marks the third indication approved for …
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TREMFYA - Treatment of Ulcerative Colitis - QUASAR Program
Nov 13, 2024 · A summary of clinical data regarding TREMFYA® (guselkumab) use in patients with ulcerative colitis (UC) from the QUASAR clinical trial program.
Official journal of the American College of Gastroenterology | ACG
The QUASAR program (NCT04033445) evaluated guselkumab (GUS), a dual-acting interleukin-23p19 subunit inhibitor, in patients (pts) with moderately to severely active ulcerative colitis (UC).
Research in Brief - The Lancet Gastroenterology & Hepatology
Guselkumab is a safe and efficacious treatment option for patients with moderately to severely active ulcerative colitis, according to the phase 3 QUASAR induction and maintenance studies.
The Efficacy and Safety of Guselkumab Induction Therapy in …
The Efficacy and Safety of Guselkumab Induction Therapy in Patients With Moderately to Severely Active Ulcerative Colitis: Phase 2b QUASAR Study Results Through Week 12 …
TREMFYA® (guselkumab) subcutaneous (SC) induction data …
Feb 21, 2025 · TREMFYA® (guselkumab) subcutaneous (SC) induction data support potential to be the first and only in its class to offer the option of both intravenous and SC induction …
S744 QUASAR Induction Study 1 Cumulative Response to …
Guselkumab (GUS), an IL-23p19 antagonist, had greater efficacy than placebo (PBO) in achieving clinical response and clinical remission at Week (Wk) 12 in the randomized, controlled Phase …
Guselkumab in Patients With Moderately to Severely Active …
Apr 27, 2023 · In a Phase 2b/3 clinical development program for guselkumab in UC (NCT04033445), the efficacy and safety of guselkumab compared with placebo is being …
Pivotal Study: Guselkumab Efficacy in Ulcerative Colitis …
Feb 3, 2025 · Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance …
THE EFFICACY AND SAFETY OF GUSELKUMAB AS …
The Phase 3 QUASAR Maintenance Study (NCT04033445) is a randomized-withdrawal, double-blind, placebo(PBO)-controlled, study that evaluated the efficacy and safety of maintenance …
QUASAR: phase 3 study of guselkumab in moderately to …
May 30, 2023 · The QUASAR Phase 3 Induction Study (NCT04033445) investigated the efficacy and safety of the IL-23 p19 subunit antagonist guselkumab in the treatment of moderately to …
Guselkumab in patients with moderately to severely active …
Jan 4, 2025 · Guselkumab is a dual-acting, human IgG1, interleukin-23p19 subunit inhibitor that potently neutralises interleukin-23 and can bind to CD64. We aimed to evaluate the efficacy …
Guselkumab in moderately to severely active ulcerative colitis: …
3 days ago · The QUASAR clinical development program evaluated the efficacy of guselkumab—an IL-23p19 subunit inhibitor—for the treatment of moderate-to-severe …
QUASAR: Guselkumab improves QoL for patients with ulcerative …
Apr 18, 2024 · In the phase 3 QUASAR trial, guselkumab induction therapy delivered clinically meaningful improvements across all measured domains of health-related quality-of-life (QoL) …
Guselkumab in moderately to severely active ulcerative colitis: …
3 days ago · The QUASAR clinical development program evaluated the efficacy of guselkumab-an IL-23p19 subunit inhibitor-for the treatment of moderate-to-severe ulcerative colitis. 1 …
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