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- A ribonucleoprotein (RNP) is a complex of ribonucleic acid and RNA-binding protein1. These complexes play an integral part in a number of important biological functions that include transcription, translation and regulating gene expression and regulating the metabolism of RNA1. RNA is a complex compound of high molecular weight that functions in cellular protein synthesis and replaces DNA as a carrier of genetic codes in some viruses2.
Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.A ribonucleoprotein (RNP) is a complex of ribonucleic acid and RNA-binding protein. These complexes play an integral part in a number of important biological functions that include transcription, translation and regulating gene expression and regulating the metabolism of RNA.en.wikipedia.org/wiki/NucleoproteinRNA, complex compound of high molecular weight that functions in cellular protein synthesis and replaces DNA (deoxyribonucleic acid) as a carrier of genetic codes in some viruses.www.britannica.com/science/RNA How RNA binding proteins interact with RNA: …
RNA binding proteins (RBPs) comprise a large class of over 2000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures and mechanisms that RBPs use to bind and regulate RNA are incredibly diverse.
RNA-protein complexes - PubMed
The recently determined structure of a complex from the U2 small nuclear ribonucleoprotein particle shows the subtleties of RNA stem-loop recognition by ribonucleoprotein modules. A …
RNA structure drives interaction with proteins
Jul 19, 2019 · Here we investigated the relationship between the structure of an RNA and its ability to interact with proteins. Analysing in silico, in vitro and in vivo experiments, we find that …
Accurate prediction of protein–nucleic acid complexes using ...
Nov 23, 2023 · We develop a single trained network, RoseTTAFoldNA, that rapidly produces three-dimensional structure models with confidence estimates for protein–DNA and …
Computational tools to study RNA-protein complexes - PMC
A definitive way to identify RNA-binding residues or study RNA-protein interfaces (i.e., amino acid residues that directly contact RNA) is to extract them from a high-resolution experimental …
RNA–protein complexes - ScienceDirect
Feb 1, 1999 · Understanding how RNA-binding proteins specifically interact with their target RNAs to form functional complexes is a key problem in structural biology, with ramifications …
Protein–RNA interactions: a structural analysis - PMC
Feb 2, 2001 · Here we present a comprehensive analysis of protein–RNA interactions at the residue and atom level, and compare them with interactions observed in protein–double …
A deep learning model for characterizing protein-RNA …
Jan 10, 2025 · Protein-RNA interactions play pivotal roles in regulating transcription, translation, and RNA metabolism. ... In a multi-layer, multi-head setting, the attention scores vary across …
Integrative Structural Biology of Protein-RNA Complexes
Jan 7, 2020 · RNA binding proteins (RBPs) aid in RNA processing and folding, and are constitutive partners in ribonucleoprotein (RNP) complexes to maintain molecular function and …
Methods to study RNA–protein interactions | Nature Methods
Feb 25, 2019 · Recent progress has expanded the number of methods for studying RNA–protein interactions in two general categories: approaches that characterize proteins bound to an RNA …
Evaluating native-like structures of RNA-protein complexes …
RNA-protein complexes underlie numerous cellular processes, including basic translation and gene regulation. The high-resolution structure determination of the RNA-protein complexes is …
Target protein:RNA: DNA complexes are enriched by capture on streptavidin magnetic beads and purified through several denaturing washes that remove nonspecific protein and nucleic acid …
A structural dissection of protein–RNA interactions based on …
We found that our proposed Pbase is an important parameter which can be used as a new determinant to distinguish protein–RNA complexes. For high and low complexes, we can more …
Molecular structure and intracellular location of five RNA : …
Sep 2, 2024 · The hrp45 protein reaches the nuclear pore complex bound to the RNA, but when the transcript enters the central channel of the nuclear pore complex, the protein is released …
The organization and regulation of mRNA-protein complexes
In a eukaryotic cell, each messenger RNA (mRNA) is bound to a variety of proteins to form an mRNA-protein complex (mRNP). Together, these proteins impact nearly every step in the life …
How RNA-Binding Proteins Interact with RNA: Molecules and …
RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures and mechanisms that RBPs …
How cells get the message: dynamic assembly and function of
Mar 12, 2013 · Global approaches are defining the full complement of proteins with RNA-binding capacity in living cells. RNA packaging by proteins begins during transcription and determines …
Integrative Structural Biology of Protein-RNA Complexes - Cell …
Thus, an integrative structural and molecular biology approach is required, tackling three key challenges: (1) identification of cognate RNA sequences; (2) collection of structural data by …
RNA-Binding Proteins Chaperone Ribonucleoprotein Complex …
Nov 27, 2019 · RNAs and ribonucleoprotein complexes (RNPs) are essential for gene expression, a process that defines cell types and enables cellular adaptation. A hallmark of RNA …
Cryo-EM structure of catalytic ribonucleoprotein complex RNase …
Jul 10, 2020 · We report a cryo-EM structure of the S. cerevisiae RNase MRP holoenzyme solved to 3.0 Å. We describe the structure of this 450 kDa complex, interactions between its …
Extracellular cold-inducible RNA-binding protein in CNS injury ...
2 days ago · The complex pathophysiology of CNS injury is comprised of primary and secondary injury. Inflammatory secondary injury is incited by damage-associated molecular patterns …
RNA structure drives interaction with proteins - PMC
Here we investigated the relationship between the structure of an RNA and its ability to interact with proteins. Analysing in silico, in vitro and in vivo experiments, we find that the amount of …
Numerous rRNA molecules form the apicomplexan mitoribosome …
5 days ago · Among these clade-specific proteins we found numerous cases of heterodimers, multi-copy proteins and protein-pairs with identical or closely related sequences or folds which …
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