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- Small cell lung cancer is a neuroendocrine tumor of the lung1. It arises from the bronchial mucosa and invades the submucosa and peribronchial connective tissue1. The cells are small, oval, with scant cytoplasm and a high mitotic count21. The microscopic (histologic) description of small cell lung cancer includes round/oval blue cells with minimal cytoplasm, finely dispersed chromatin, no distinct nucleoli, molding, smudging, high mitotic rate, thin, delicate, scant, fibrovascular stroma, and common necrosis and apoptosis of individual cells2.
Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.Small cell lung cancer is considered a neuroendocrine tumor of the lung. It arises from the bronchial mucosa. Local invasion occurs in the submucosa with subsequent invasion of peribronchial connective tissue. Cells are small, oval, with scant cytoplasm and a high mitotic count.radiopaedia.org/articles/small-cell-lung-cancer-4Microscopic (histologic) description Round / oval blue cells with minimal cytoplasm; usually small to medium sized Nuclear features: finely dispersed chromatin, no distinct nucleoli, molding, smudging, high mitotic rate Stroma: thin, delicate, scant, fibrovascular Necrosis and apoptosis of individual cells commonwww.pathologyoutlines.com/topic/lungtumorsmallc… Small cell carcinoma - Pathology Outlines
Sep 20, 2022 · Small cell lung cancer is histologically described as small round / oval cells with high nuclear to cytoplasmic ratio. The nuclei have finely dispersed or salt and pepper chromatin and absent nucleoli. Small cell lung cancer is most often located at the hilum and grows along …
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Lung Squamous cell carcinoma (0 - 8%) (Pathology 2019;51:240, Histopathology …
Pathology and Classification of SCLC - PMC
Small cell lung carcinoma (SCLC), is a high-grade neuroendocrine carcinoma defined by its aggressiveness, poor differentiation, and somber prognosis. This review highlights current pathological concepts including classification, …
Small Cell Lung Cancer - StatPearls - NCBI Bookshelf
Jul 10, 2023 · Lung cancer is histologically divided into 2 main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Treatment is highly dependent on stage. Patients with limited-stage SCLC are candidates for …
Small cell lung cancer | Radiology Reference Article
Oct 11, 2023 · Small cell lung cancer (SCLC), also known as oat cell lung cancer, is a subtype of bronchogenic carcinoma separated from non-small-cell lung cancer (NSCLC) as it has a …
Small cell carcinoma of the lung - Libre Pathology
See more on librepathology.org- Strong association with smoking.
- Typically treated with chemotherapy.
- Poor prognosis.
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Small-cell lung cancer - PMC - PubMed Central (PMC)
Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by an exceptionally high proliferative rate, strong predilection for early metastasis and poor …
Small Cell Lung Carcinoma: Current Diagnosis, Biomarkers, and …
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid proliferation, early dissemination, acquired therapy resistance, and poor prognosis. Early diagnosis of …
Pathology of small cell carcinoma of the lung - ScienceDirect
Feb 1, 2003 · Small cell lung cancer is an aggressive neoplasm, which is reflected in its high-grade morphology, evident in both cytologic and histologic preparations. The diagnosis should …
Pathology of small-cell lung cancer - PubMed
Apr 23, 2021 · Together with "large-cell neuroendocrine carcinomas" and typical or atypical carcinoid tumors, small-cell lung cancers are currently histogenetically categorized as …
Pathology and Classification of SCLC - MDPI
Dec 21, 2020 · Small cell lung carcinoma (SCLC), is a high-grade neuroendocrine carcinoma defined by its aggressiveness, poor differentiation, and somber prognosis. This review highlights current pathological concepts including …
Pathology of small-cell lung cancer | Journal of Cancer Research …
Together with “large-cell neuroendocrine carcinomas” and typical or atypical carcinoid tumors, small-cell lung cancers are currently histogenetically categorized as neuroendocrine lung …
Histopathology images-based deep learning prediction of ... - Nature
Jan 18, 2024 · Small cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer characterized by rapid tumor growth and early metastasis. Accurate prediction of prognosis …
Update on small cell carcinoma and its differentiation from …
Jan 3, 2012 · Historically, there has been significant evolution in the histological subclassification of SCLC dating from 1962 when Kreyberg proposed the oat cell and polygonal cell types. The …
Small-cell lung cancer - The Lancet
Oct 15, 2005 · Small-cell lung carcinoma is an aggressive form of lung cancer that is strongly associated with cigarette smoking and has a tendency for early dissemination. Increasing …
Lung Cancer Pathology: Current Concepts - PubMed
Lung cancer can be diagnosed based on histologic biopsy or cytologic specimens. The 2015 World Health Organization Classification of Lung Tumors addressed the diagnosis of lung …
Small cell lung cancer profiling: an updated synthesis of subtypes ...
Oct 1, 2024 · Transcriptionally defined small cell lung cancer (SCLC) subtypes represent dynamic cell states rather than static phenotypes. Subtype conversions appear to most commonly favor …
SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, …
We review research regarding the epidemiology, risk factors, genetic susceptibility, molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of lung cancers. …
Small Cell Carcinoma - WebPathology
In small cell lung carcinoma (SCLC), the tumor cells are small (usually less than 3 times the diameter of small resting lymphocytes), round, oval or spindle shaped with scant cytoplasm …
Your Lung Pathology Report - American Cancer Society
Squamous cell carcinoma in situ (SCIS) is a pre-cancer that can become invasive squamous cell carcinoma (a type of non-small cell lung cancer). Adenocarcinoma in situ (AIS) is a pre-cancer …
Radiomics for differentiating adenocarcinoma and squamous cell ...
Dec 30, 2024 · Scagliotti, G. et al. Treatment-by-histology interaction analyses in three phase III trials show superiority of pemetrexed in nonsquamous non-small cell lung cancer. J. Thorac.
Non-small cell lung cancer in ever-smokers vs never-smokers
1 day ago · Lung cancer is a leading cause of cancer-related mortality. Non-small cell lung cancer (NSCLC) comprises 85% of cases with rising incidence among never-smokers (NS). This …
Small cell lung cancer: etiology, biology, clinical features, staging ...
Small cell lung cancer (SCLC) accounts for 20% to 25% of all bronchogenic carcinoma and is associated with the poorest 5-year survival of all histologic types. SCLC differs in its etiologic, …
Evaluation of an enhanced ResNet-18 classification model for …
2 days ago · Objective Rapid on-site evaluation (ROSE) of respiratory cytology specimens is a critical technique for accurate and timely diagnosis of lung cancer. However, in China, limited …
Journal of Cutaneous Pathology - Wiley Online Library
2 days ago · Pemetrexed is a chemotherapeutic, antimetabolite agent that has been used in oncology to treat diseases such as metastatic non-small cell lung cancer and unresectable …
Predicting the tumor microenvironment composition and …
Subject terms: Cancer imaging, Cancer microenvironment, Non-small-cell lung cancer, Tumour biomarkers. Introduction. Lung cancer is the leading cause of cancer-related mortality globally, …
Implementing Trust in Non-Small Cell Lung Cancer Diagnosis …
Dec 28, 2024 · Ensuring trustworthiness is fundamental to the development of artificial intelligence (AI) that is considered societally responsible, particularly in cancer diagnostics, where a …
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