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- SHH gene
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Sonic hedgehog protein - Wikipedia
Sonic hedgehog protein (SHH) is encoded for by the SHH gene. The protein is named after the video game character Sonic the Hedgehog. This signaling molecule is key in regulating embryonic morphogenesis in all animals. SHH controls organogenesis and the organization of the central nervous … See more
The hedgehog gene (hh) was first identified in the fruit fly Drosophila melanogaster in the classic Heidelberg screens of Christiane Nüsslein-Volhard and Eric Wieschaus, as published in 1980. These See more
A potential inhibitor of the Hedgehog signaling pathway has been found and dubbed "Robotnikinin"—after Sonic the Hedgehog's nemesis … See more
• SHH gradient and Gli activity in the vertebrate neural tube
• Processing of SHH
• Concentration gradient of SHH See more
Of the hh homologues, SHH has been found to have the most critical roles in development, acting as a morphogen involved in patterning many systems—including the anterior pituitary, pallium of the brain, spinal cord, lungs, teeth and the See more
The gene has been linked to a condition known as holoprosencephaly, which can result in severe brain, skull and facial defects, causing a few clinicians and scientists to criticize the name on the grounds that it sounds too frivolous. It has been noted that … See more
Wikipedia text under CC-BY-SA license SHH Gene - Sonic Hedgehog Signaling Molecule
Dec 25, 2024 · SHH is a protein coding gene that encodes a signaling molecule involved in embryonic patterning and development. It is related to several disorders, such as holoprosencephaly, VACTERL syndrome, and polydactyly.
SHH gene - MedlinePlus
The SHH gene encodes a protein that is essential for embryonic development of the brain, eyes, and limbs. Mutations in the gene can cause holoprosencephaly, a condition that affects the brain and face.
Sonic hedgehog signalling pathway: a complex …
Sonic Hedgehog (Shh) signalling cascade is one of the intricate signal transduction mechanisms that govern the precisely regulated developmental processes of multicellular organisms. Along with establishing the patterns of …
The Role of Sonic Hedgehog Pathway in the …
The Sonic hedgehog (SHH) pathway affects neurogenesis and neural patterning during the development of the central nervous system. Dysregulation of the SHH pathway in the brain contributes to aging-related neurodegenerative diseases …
Developmental Signals - Sonic hedgehog
Mar 7, 2025 · Sonic Hedgehog was isolated by homology to the Hedgehog (Hh) gene. A single Hh homolog is present in Drosophila, but three Hh homologs, Sonic Hh, Indian Hh, and …
SHH sonic hedgehog signaling molecule [ Homo sapiens (human) ]
164 rows · Feb 8, 2025 · It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human …
Sonic hedgehog - PMC
Mammals have three genes with homology to the hh gene. These comprise Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh). 1 All hedgehog genes encode …
The Hedgehog Signaling Pathway in Vertebrates
Jun 27, 2016 · There are three classes of vertebrate hh genes: Sonic hedgehog, Indian hedgehog, and Desert hedgehog, with most vertebrate species possessing one member from each gene …
Entry - *600725 - SONIC HEDGEHOG SIGNALING MOLECULE; …
SHH is a gene that encodes a secreted protein involved in cell fate determination during development. It is related to the Drosophila gene hedgehog and has several mammalian …
Sonic Hedgehog Gene - The Hedgehog Program
May 31, 2023 · Did you know that all species, mankind, and animal, that have two eyes have the same gene that separate your left brain from your right, causing for you to have two eyes? …
Sonic Hedgehog, a key development gene, experienced …
Jul 1, 2006 · Sonic Hedgehog (SHH) is one of the most intensively studied genes in developmental biology. It is a highly conserved gene, found in species as diverse as …
Sonic Hedgehog Signaling in Limb Development - Frontiers
Feb 27, 2017 · Over 20 years ago the first evidence was presented that Sonic hedgehog (Shh), an orthologue of the Drosophila Hedgehog (Hh) gene, encodes the long sought after morphogen …
Sonic Hedgehog gene - WikiLectures
Sonic Hedgehog gene is probably the best-known member of the hedgehog (hh) family, i.e. a family of genes whose products are signal molecules that are very effective especially in …
Hedgehog signaling pathway: Video, Causes, & Meaning - Osmosis
The hedgehog signalling pathway is a pathway based on three specific proteins called the hedgehog proteins. The most well-studied of these proteins is the Sonic hedgehog protein, or …
Multiple roles of Sonic Hedgehog in the developing human cortex …
Sonic Hedgehog (Shh) plays an instrumental role in brain development, fine-tuning processes such as cell proliferation, patterning, and fate specification. Although, mutations in the SHH …
Expression of the Sonic hedgehog (SHH ) gene during early …
Holoprosencephaly (HPE), the most common developmental defect of the forebrain and the face, is genetically heterogeneous. One of the genes involved, Sonic hedgehog ( SHH ), on 7q36, …
Sonic hedgehog - Molecular Pathology
Mammals have three genes with homology to the hh gene. These comprise Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh). 1 All hedgehog genes encode …
How the sonic hedgehog (SHH) gene got its name - FlipScience
Dec 1, 2020 · The sonic hedgehog gene is a remarkable part of our anatomy—and proof that scientists have a sense of humor. Read the humorous tale of how it got its name.
Sonic hedgehog - (General Biology I) - Fiveable
Sonic hedgehog is critical for the development of the neural tube, influencing the formation of the brain and spinal cord. Mutations in the Sonic hedgehog gene can lead to congenital defects …
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