Created in 1971, Amtrak originally operated from St. Louis Union Station. However, when it became apparent that there were no longer enough trains serving St. Louis to justify the use of such a large facility, Union Station was abandoned in November 1978. Amtrak then moved to a modular structure two blocks east, at 550 S. 16th St; the new station was originally approved on a site west of Union Station in 1976, with a budget of $6.4 million. Intended for temporary use, this station—soon dubbed "Amshack"—remained in service for 26 years, even after Union Station reopened and long past the end of its useful life. On December 20, 2004, Amtrak moved across the street to 551 South 16th Street, a 4,000-square-foot (370 m ) masonry and steel "interim" structure built at an estimated cost of $600,000. The building now houses Amtrak operating and mechanical crews.

• Missouri portal
• List of Amtrak stations
• List of intercity bus stops in Missouri

Media related to Gateway Multimodal Transportation Center at Wikimedia Commons
• St. Louis, MO – Amtrak
• St. Louis, MO – Station history at Great American Stations (Amtrak)
• Status of Amtrak's Texas Eagle trains through St. Louis Archived December 5, 2008, at the Wayback Machine
• Former St. Louis Amtrak Stations (USA RailGuide -- TrainWeb)