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: an act, process, or instance of transcribing. : an arrangement of a musical composition for some instrument or voice other than the original. : a recording (as on magnetic tape) made …

Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extra-cellular signals, to define cell identity during …

19 hours ago · Transcriptional activation is deeply intertwined with intracellular signaling networks that relay environmental and cellular cues to the nucleus. These pathways influence gene …

Aug 14, 2023 · Transcription is the process where a specific segment of DNA is used as a template and copied into an RNA molecule. This synthesis is carried out by an enzyme known …

Jan 14, 2025 · Learn how eukaryotic genes are transcribed into RNA by RNA polymerase II and its associated factors. Discover the stages, mechanisms, and regulators of eukaryotic …

Here we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease. …

Learn how DNA is copied to RNA and RNA to protein in cells, and the roles of RNA polymerases, transcription factors, and tRNAs. Explore the structure and function of genes, mRNA, and the …

Aug 28, 2019 · Recent structural studies have elucidated mechanisms that govern the regulation of transcription by RNA polymerases during the initiation and elongation phases. Microscopy …

Aug 31, 2023 · Learn how transcriptional regulators bind to DNA sequences and control gene expression in prokaryotes and eukaryotes. Explore the lac operon, enhancers, and promoters …

4 hours ago · In experiments where transcriptional activation was blocked, the mutation rate dropped nearly 60-fold, demonstrating a clear causal relationship between gene expression …

Nov 8, 2024 · In this Review, we discuss the principles underlying the regulation of transcriptional condensates, their roles in physiology and their dysregulation in human diseases.

In biology, the process by which a cell makes an RNA copy of a piece of DNA. This RNA copy, called messenger RNA (mRNA), carries the genetic information needed to make proteins in a …

The bacterialRNA polymerase, a leading enzyme involved in formation of a transcription bubble, uses DNA template to guide RNA synthesis. [7] It is present in two main forms: as a core …

3 days ago · Recurrent implantation failure (RIF) is a devastating condition that leaves many undergoing fertility treatment childless. The human endometrium is receptive to a blastocyst …

Dec 30, 2022 · The process of copying DNA into RNA is called transcription. In both prokaryotes and eukaryotes, transcription requires certain control elements (sequences of nucleotides …

Transcription is the process by which RNA is made from genomic DNA. DNA is a linear polymer composed of four nucleotides, deoxyadenosine, deoxyguanosine, deoxycytosine and …

This emerging field promises to offer an unprecedented understanding of how transcriptional and post-transcriptional regulation generates complex gene expression programs by fine tuning …

As in bacteria, transcription in eukaryotic cells is controlled by proteins that bind to specific regulatory sequences and modulate the activity of RNA polymerase.

In Kras mutant lung cancer cells, we found that HDAC3 is a direct transcriptional repressor of a cassette of secreted chemokines, including Cxcl10. Genetic and pharmacological inhibition of …