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    Cationic liposome - Wikipedia

    Cationic liposomes are spherical structures that contain positively charged lipids. Cationic liposomes can vary in size between 40 nm and 500 nm, and they can either have one lipid bilayer (monolamellar) or multiple lipid bilayers (multilamellar). The positive charge of the phospholipids allows cationic … See more

    In the 1960s, Alec D. Bangham discovered liposomes as concentric lipid bilayers surrounding an aqueous center, based on his research at the University of Cambridge … See more

    The use of cationic lipids helps to enhance the overall stability and efficiency of liposomes. Although cationic lipids themselves are able to encapsulate nucleic acids into liposomes, the transfection efficiency is low due to a process known as See more

    Cancer Drug Delivery
    EndoTAG-1
    Paclitaxel (PTX) is a chemotherapy medication used to … See more

    Cytotoxicity
    The positive charge of cationic lipids has been shown to have cytotoxic effects, as these lipids can activate several pro-apoptotic and pro-inflammatory cell signaling pathways. The cationic nature of these lipids is … See more

    Delivery Mechanism in vivo image

    Cationic liposomes are manufactured similarly to liposomes. There are multiple processes that can be used to form cationic liposomes, such as sonication, extrusion, … See more

    Cationic liposomes can deliver nucleic acids into the cell through an endocytotic pathway or through cell membrane fusion. Fusogenic cationic liposomes almost exclusively deliver nucleic acids through cell membrane fusion. The fusion between positively charged … See more

     
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