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  1. Dictionary
    break·through
    [ˈbrākˌTHro͞o]
    noun
    breakthrough (noun) · breakthroughs (plural noun) · break-through (noun) · break-throughs (plural noun)
    1. a sudden, dramatic, and important discovery or development:
      "a major breakthrough in DNA research"
      • an instance of achieving success in a particular sphere or activity:
        "her big breakthrough came on the stage when she won a Tony Award in 1958" · "the band's breakthrough album"
    2. denoting a symptomatic case of a disease occurring despite preventative medication, vaccination, or prior infection:
      "we're seeing more and more of these breakthrough infections"
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