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  2. Female calico cats have two X chromosomes, and therefore have two chromosomes with color code. Only if the cat gets one orange-coded X and one black-coded X, will she be calico, expressing both black and orange coloration.
    www.thesprucepets.com/are-calico-cats-always-fe…
    Calico cats are well known for being almost exclusively female, but is this based in fact or just another widespread myth? It turns out that this is 100% true! Except under rare genetic conditions, Calico cats are almost always female. There are fascinating reasons for this, which we detail here.
    petkeen.com/are-calico-cats-always-female/
    Calico cats are almost always female because the locus of the gene for the orange/non-orange coloring is on the X chromosome. In the absence of other influences, such as color inhibition that causes white fur, the alleles present in those orange loci determine whether the fur is orange or not.
    en.wikipedia.org/wiki/Calico_cat
    Calico’s are 99.99% female due to the X chromosome determining the cat’s coloring. ‘XX’ (female chromosomes) means multiple colors can show up, while ‘XY’ (male) means usually only one color can be present.
    www.rover.com/blog/calico-kittens-everything-you-…
    Yes, female calico cats can reproduce. However, they are usually sterile and cannot have kittens of their own. Calico cats are born white and their fur changes color as they grow older. The reason why female calico cats are usually sterile is because they have two X chromosomes, one of which is carrying the gene for the calico coat.
    catscaress.com/can-female-calico-cats-reproduce/
     
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    WEBLearn about the different types of calico cat colours, how they are inherited, and what makes them unique. Calico cats are almost always female and have patches of black, brown or grey, and red or cream with white.

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