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Jun 20, 2022 · Here, we report that MSR transcripts can drive the formation of HP1ɑ droplets in vitro, and modulate heterochromatin into dynamic condensates in ESCs, contributing to the …

Feb 21, 2023 · In this study, we discover that RNA-binding protein LSM1-mediated major satellite RNA decay plays a central role in the preferential incorporation of histone variant H3.3 into the …

Sep 18, 2023 · In certain stress or pathological conditions, satellite RNAs are induced to assemble mesoscopic membraneless organelles. Specifically, under heat stress, nuclear stress bodies …

Jan 16, 2020 · Major satellite (MajSAT) RNAs stabilize PCH retention of H3K9me3 methyltransferases (i.e., Suv39h enzymes) by forming a DNA-RNA hybrid (Velazquez …

In somatic cells, mitotic transcription of major satellite non-coding RNAs is tightly regulated and essential for heterochromatin formation and the maintenance of genome integrity. We recently …

Jun 4, 2021 · We explored whether these heterochromatic RNA, similar to DNA and histones, may be methylated, particularly for 5-methylcytosine (5mC) or methyl-6-adenosine (m6A). Our …

May 17, 2021 · Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.

Oct 19, 2010 · Remarkably, our qualitative analysis using RNA-FISH shows that major satellite transcripts exhibit unexpected strand-specific expression patterns and localization. Whereas …

Dec 8, 2020 · We describe the first evidence of a role in neurons for MeCP2 and MajSat forward (MajSat-fw) RNA in reciprocal targeting to PCH through their physical interaction. Moreover, …

Jan 16, 2020 · Here, we show that scaffold attachment factor B (SAFB), a nuclear matrix (NM)-associated protein with RNA-binding functions, modulates chromatin condensation and …

satRNAs are linear-single stranded (ss) RNA molecules exhibiting the following traits: (1) satRNA parasitizes on helper virus (HV) replication machinery (2) satRNA is encapsidated by the HV …

Satellite DNAs are considered a major source of heterochromatin in the nucleus, but it has been revealed that each class of satellite DNA is transcribed to produce satellite RNA under specific …

Aug 1, 2017 · We show here that the mouse Suv39h2 enzyme differs from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic chromatin and provides an …

A satellite is a subviral agent that depends on the coinfection of a host cell with a helper virus for its replication. Satellites can be divided into two major groups: satellite viruses and satellite …

Feb 24, 2025 · The RNA velocity map showed that myocytes developed from myoblasts, and myoblasts developed from muscle satellite cells, due to the high RNA velocity that began …

Feb 21, 2023 · LSM1 interacts with major satellite RNA and regulates its decay. Then, we traced the clues regarding LSM1’s action to clarify the mechanism of the establishment and …

Aug 1, 2017 · Together, these data reveal an RNA-mediated mechanism for the stable chromatin interaction of the Suv39h KMT and suggest a function for major satellite non-coding RNA in …

3 days ago · In this Review, Penadés et al. explore the genetics, potential origins and life cycle of phage satellites, and they discuss the impact of these elements on the evolution of other …