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    Monolithic HPLC column - Wikipedia

    • A monolithic HPLC column, or monolithic column, is a column used in high-performance liquid chromatography (HPLC). The internal structure of the monolithic column is created in such a way that many channels form inside the column. The material inside the column which separates the channels can be porous and functionalized. In contrast, most HPL… See more

    Technology overview

    In analytical chromatography, the goal is to separate and uniquely identify each of the compounds in a … See more

    Technology development

    The roots of liquid chromatography extend back over a century ago to 1900, when Russian botanist Mikhail Tsvet began experimenting with plant pigments in chlorophyll. He noted that, when a solvent was applie… See more

    Technology life cycle

    Silica monoliths have only been commercially available since 2001, when Merck began their Chromolith campaign. The Chromolith technology was licensed from Soga and Nakanishi's group at Kyoto University. … See more

    Industry evolution

    Liquid chromatography as we know it today really got its start in 1969, when the first modern HPLC was designed and marketed as a nucleic acid analyzer. Columns throughout the 1970s were unreliable, pump flow r… See more

    Technology applications

    In its earliest form, liquid chromatography was used to separate the pigments of chlorophyll by a Russian botanist. Decades later, other chemists used the procedure for the study of carotins. Liquid chromatograp… See more

    Industry applications

    The liquid chromatography marketplace is incredibly diverse. Five to ten firms are consistently market leaders, yet nearly half of the market is made up of small, fragmented companies. This section of the report will f… See more

    Economic impact

    Though the many advances of HPLC and monoliths are highly visible within the confines of the analytical and pharmaceutical industries, it is unlikely that general society is aware of these developme… See more

     
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  2. A monolithic HPLC column, or monolithic column, is a column used in high-performance liquid chromatography (HPLC). The internal structure of the monolithic column is created in such a way that many channels form inside the column. The material inside the column which separates the channels can be porous and functionalized.
    en.wikipedia.org/wiki/Monolithic_HPLC_column
    Monolithic columns are a special type of chromatography column, which can be used for the purification of different biomolecules. They have become popular due to their high mass transfer properties and short purification times.
    www.mdpi.com/2227-9075/2/2/195
     
  3. Monolithic Columns For Chromatography - Sartorius

    With flow-independent performance, low back-pressure, and versatility our monolithic columns facilitate faster purification of your viruses or nucleic acids. CIM ® monoliths are available in a variety of chemistries and sizes ranging …

     
  4. Monolithic column - Wikipedia

    A monolithic column or single-piece column is a large column of which the shaft is made from a single piece of stone instead of in vertical sections. Smaller …

    • Estimated Reading Time: 5 mins
    • An Overview of Monolithic Column: Types, …

      Aug 15, 2022 · Nowadays, monolithic columns are graining more popularity in the field of separation media for liquid chromatography. The monolith columns possess great potential as compared to the...

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      Dec 4, 2013 · Monolithic columns are either silica-based or have organic polymer backbones. Richard Synge in 1952 conceptualized monolith as a continuous block of porous gel. The idea picked up in 60s and 70s when polyurethane …

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