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In this review, we break from this format as we cover a more mature scientific area, RNA folding, and we describe general insights drawn from RNA’s molecular behavior and glean lessons …

In parallel with the efforts to establish the nature of the genetic code and the decoding process, it was determined that the amino acid sequence of a protein contains the protein folding code, …

Sep 30, 2022 · Utilizing proteins as dynamic RNA folding chaperones could allow advantageous modularity, allowing the RNA sequence to develop into highly specialized final structural states …

Apr 5, 2005 · RNA and protein folding mechanism can be described by the kinetic partitioning mechanism (KPM) according to which a fraction (Phi) of molecules reaches the native state …

From the perspective of an RNA strand, a protein could be a useful tool to facilitate its folding through specific binding or nonspecific (predominantly electrostatic) association. There are …

Nov 27, 2019 · Ribosome assembly is an efficient but complex and heterogeneous process during which ribosomal proteins assemble on the nascent rRNA during transcription. Understanding …

In the cell, most proteins have their first opportunity to fold during their synthesis via translation. Protein synthesis occurs orders of magnitude slower than the rate of formation of α-helices …

RNA-binding proteins can help solve both RNA folding problems. Nonspecific RNA-binding proteins 1 solve the kinetic folding problem in vivo by acting as RNA chaperones that prevent …

RNA folding is the most essential process underlying RNA function. While significant progress has been made in understanding the forces driving RNA folding in vitro, exploring the rules …

Dec 15, 2016 · These findings suggest a model in which the mRNA structure, particularly exceptionally stable RNA structural elements, act as gauges of protein co-translational folding …

Feb 12, 2025 · As a result, users should exercise caution when using AlphaFold3 predictions as hypotheses generators for RNA and protein-RNA complex structures. In the interim, …

Nov 1, 2021 · Ribonucleoprotein (RNP) assembly typically begins during transcription when folding of the newly synthesized RNA is coupled with the recruitment of RNA-binding proteins …

Nov 1, 2010 · RNA folding is the most essential process underlying RNA function. While significant progress has been made in understanding the forces driving RNA folding in vitro, exploring the …

In this review, we break from this format as we cover a more mature scientific area, RNA folding, and we describe general insights drawn from RNA’s molecular behavior and glean lessons …

Ribonucleoprotein (RNP) assembly typically begins during transcription when folding of the newly synthesized RNA is coupled with the recruitment of RNA-binding proteins (RBPs). Upon …

Nov 27, 2019 · This work questions the paradigm of strictly sequential and cooperative ribosome assembly and suggests that transient binding of RNA binding proteins to cellular RNAs could …

Feb 11, 2025 · “Protein folding, and how well we maintain this process, is fundamental to pretty much every disease. But so far, we look at these diseases as separate end points, treating the …

RNA folding in vivo is influenced by the cellular environment, the vectorial nature of transcription and translation, trans-acting factors and ion homeostasis. Specific RNA-binding proteins …

Trans-acting factors such as proteins, RNAs and metabolites, among others, are also able to modulate the structure and thus the fate of an RNA. Here we summarize the ongoing efforts to …

Feb 12, 2025 · Thioredoxin Related Transmembrane Protein 1 (TMX1) encodes a thiol-disulfide oxidoreductase and regulates cleavage, formation, or isomerization of disulfide bonds among …

Jan 16, 2025 · In eukaryotic cells, the genomic DNA is packaged into chromatin, a highly organized complex of nucleic acids and proteins. The nucleosome, the fundamental repeating …