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Tirzepatide as Compared with Semaglutide for the Treatment of …
May 11, 2025 · In this phase 3b, open-label, controlled trial, adult participants with obesity but without type 2 diabetes were randomly assigned in a 1:1 ratio to receive the maximum …
Zongertinib in Previously Treated - The New England Journal of …
Apr 28, 2025 · In cohort 1, a total of 75 patients received zongertinib at a dose of 120 mg. At the data cutoff (November 29, 2024), 71% of these patients (95% confidence interval [CI], 60 to …
Lorundrostat Efficacy and Safety in Patients with Uncontrolled ...
Apr 23, 2025 · Uncontrolled hypertension remains a leading cause of cardiovascular complications and death from cardiovascular disease. 1 Despite the use of multidrug …
Phase 3 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis
Apr 23, 2025 · A total of 1721 patients (1680 adults and 41 adolescents) underwent randomization and received brensocatib or placebo. The annualized rate of pulmonary exacerbations was …
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic …
May 15, 2025 · Targeted DNA Methylation Using Modified DNA Probes: A Potential Therapeutic Tool for Depression and Stress-Related Disorders, International Journal of Molecular …
Encorafenib, Cetuximab, and mFOLFOX6 in - The New England …
May 30, 2025 · First-line treatment with encorafenib plus cetuximab (EC) with or without chemotherapy (oxaliplatin, leucovorin, and fluorouracil [mFOLFOX6]) for BRAF …
Tezepelumab in Adults with Severe Chronic Rhinosinusitis with …
Mar 1, 2025 · Tezepelumab is a human monoclonal antibody that specifically blocks TSLP from interacting with its heterodimeric receptor. 21,22 Tezepelumab administered subcutaneously …
Sotatercept in Patients with Pulmonary Arterial Hypertension at …
Mar 31, 2025 · In this phase 3 trial, we randomly assigned patients with pulmonary arterial hypertension (WHO functional class III or IV) and a high 1-year risk of death (Registry to …
Lepodisiran - The New England Journal of Medicine
Mar 30, 2025 · Elevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small …
Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis
Feb 7, 2025 · Despite treatment advances in lupus nephritis, including regulatory approvals of belimumab and voclosporin, 1,2 the goal to sufficiently improve short- and long-term outcomes …
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