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- Lorlatinib vs. Crizotinib in ALK-positive non-small cell lung cancer:
- In the first-line setting, alectinib showed a significant advantage over crizotinib and had the longest overall survival (OS) among all ALK-inhibitors.
- Lorlatinib had the best efficacy regarding progression-free survival (PFS) for global patients, followed closely by alectinib and brigatinib.
- Updated data from the CROWN trial show the durable benefit of lorlatinib over crizotinib in treatment-naive patients with ALK-positive NSCLC, supporting its use as a first-line treatment123.
Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.In the first-line setting, alectinib showed a significant advantage over crizotinib and had the longest OS among all ALK-inhibitors. Compared to crizotinib, lorlatinib had the best efficacy regarding PFS for global patients, followed closely by alectinib and brigatinib.bmccancer.biomedcentral.com/articles/10.1186/s12…These updated, long-term data from CROWN show the durable benefit of lorlatinib over crizotinib in patients with treatment-naive, ALK-positive non-small-cell lung cancer and support the use of first-line lorlatinib in patients with and without baseline brain metastases.europepmc.org/article/MED/36535300As reported in The New England Journal of Medicine by Alice T. Shaw, MD, PhD, and colleagues, an interim analysis of the phase III CROWN trial has shown that first-line lorlatinib significantly improved progression-free survival and intracranial response rate vs crizotinib in patients with advanced ALK -positive non–small cell lung cancer (NSCLC).ascopost.com/news/november-2020/first-line-lorlati… - People also ask
First-Line Lorlatinib or Crizotinib in Advanced
WEBNov 18, 2020 — Lorlatinib was associated with more grade 3 or 4 adverse events (mainly altered lipid levels) than crizotinib (in 72% vs. 56%).
- Author: Alice T. Shaw, Todd M. Bauer, Filippo de Marinis, Enriqueta Felip, Yasushi Goto, Geoffrey Liu, Julie...
- Publish Year: 2020
Lorlatinib Versus Crizotinib in Patients With Advanced
WEBLorlatinib improved progression-free survival (PFS) and intracranial activity versus crizotinib in patients with previously untreated, advanced, ALK -positive non–small cell lung cancer (NSCLC) in the phase III CROWN …
- Studies of lorlatinib vs crizotinib
Efficacy and safety of first-line lorlatinib versus …
WEBDec 16, 2022 — Of 112 patients without baseline brain metastases, only one patient developed new intracranial lesions on lorlatinib treatment. The 50-fold reduction in time to intracranial progression with lorlatinib versus …
First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung ...
WEBNov 19, 2020 — Lorlatinib was associated with more grade 3 or 4 adverse events (mainly altered lipid levels) than crizotinib (in 72% vs. 56%). Discontinuation of treatment …
Lorlatinib vs crizotinib in treatment-naïve patients with advanced
WEBJun 5, 2024 — Background: Lorlatinib, a brain-penetrant, 3rd-generation ALK tyrosine kinase inhibitor, demonstrated improved progression-free survival (PFS) and intracranial (IC) …
Lorlatinib Versus Crizotinib in Patients With Advanced
WEBPurpose: Lorlatinib improved progression-free survival (PFS) and intracranial activity versus crizotinib in patients with previously untreated, advanced, ALK-positive non …
WEBfree survival in the lorlatinib group, patients who received lorlatinib had significantly longer progression-free survival versus crizotinib (hazard ratio 0·28 [95% CI 0·19–0·41]), and …
Lorlatinib versus Crizotinib in Advanced ALK -Positive …
WEBNov 18, 2020 — The ALK inhibitor crizotinib was shown to be superior to platinum-based chemotherapy as first-line therapy for NSCLC; subsequent trials showed that second-generation agents were superior to...
992P Updated analyses from the CROWN study of first-line …
WEBLorlatinib improved progression-free survival (PFS) and demonstrated intracranial (IC) activity in patients with untreated advanced ALK + non-small cell lung cancer (NSCLC) …
Efficacy and safety of first-line lorlatinib versus crizotinib in ...
WEBProgression-free survival (investigator), objective response rate, intracranial objective response rate, time to intracranial progression, and duration of response were improved …
First-Line Lorlatinib Versus Crizotinib in ALK -Positive …
WEBFeb 2, 2023 — Lorlatinib, a third-generation ALK inhibitor, was found to have improved efficacy versus crizotinib in patients with previously untreated, advanced ALK-positive NSCLC in the ongoing, global, …
Efficacy and safety of first-line lorlatinib versus crizotinib in ...
WEBDec 16, 2022 — These updated, long-term data from CROWN show the durable benefit of lorlatinib over crizotinib in patients with treatment-naive, ALK-positive non-small-cell …
WEBMay 31, 2024 — PURPOSE Lorlatinib improved progression-free survival (PFS) and intracranial activity versus crizotinib in patients with previously untreated, advanced, …
WEBBackground: Lorlatinib, a brain-penetrant, 3rd-generation ALK tyrosine kinase inhibitor, demonstrated improved progression-free survival (PFS) and intracranial (IC) activity vs …
Lorlatinib vs Crizotinib in Advanced ALK-Positive NSCLC: 5-Year ...
WEBAug 25, 2024 — In this international open-label trial, 296 patients with ALK -positive NSCLC were randomly assigned to receive lorlatinib at 100 mg once daily (n = 149) or crizotinib …
WEBNov 19, 2020 — We conducted a global, randomized, phase 3 trial comparing lorlatinib with crizo-tinib in 296 patients with advanced ALK-positive NSCLC who had received no …
Redefining Recovery: The Transformative Impact of the ALINA …
WEBAug 28, 2024 — In this study, lorlatinib notably outperformed crizotinib, with a median progression-free survival (PFS) not yet reached, compared to 9.3 months for crizotinib. …
1197P First-line lorlatinib versus crizotinib in ALK-positive non …
WEBLorlatinib, a 3rd-generation ALK inhibitor, significantly prolonged progression-free survival (PFS) vs crizotinib in the CROWN trial in patients with untreated ALK -positive non-small …
WEBLorlatinib, a 3rd generation ALK tyrosine kinase inhibitor has shown overall and intracranial (IC) activity in advanced ALK+ NSCLC. We report interim data from an open label …
Lorlatinib vs Crizotinib for Advanced - ASCO Post
WEBMay 31, 2024 — Coupled with durable intracranial efficacy and the absence of new safety signals with lorlatinib, “these results indicate an unprecedented improvement in …
Phase 3 trial of lorlatinib in treatment-naive patients (Pts) with
WEBJun 2, 2022 — In the randomized, multicenter, phase 3 study in pts with previously untreated ALK+ advanced NSCLC (CROWN; NCT03052608), lorlatinib showed a statistically …
First-Line Lorlatinib Versus Crizotinib in ALK -Positive NSCLC ...
WEBFeb 2, 2023 — Lorlatinib, a third-generation ALK inhibitor, was found to have improved efficacy versus crizotinib in patients with previously untreated, advanced ALK -positive …
Lorlatinib vs Crizotinib in Previously Untreated Advanced
WEBJun 18, 2024 — In the international, open-label trial, 296 patients with ALK-positive NSCLC were randomly assigned to receive lorlatinib at 100 mg once daily (n = 149) or crizotinib …
LBA2 Lorlatinib vs crizotinib in the first-line treatment of patients ...
WEBLorlatinib, a 3rd generation ALK tyrosine kinase inhibitor has shown overall and intracranial (IC) activity in advanced ALK+ NSCLC. We report interim data from an open label …
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