melanocyte location in skin - Search
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  2. Melanocyte - Wikipedia

    • Melanocytes are melanin-producing neural crest-derived cells located in the bottom layer (the stratum basale) of the skin's epidermis, the middle layer of the eye (the uvea), the inner ear, vaginal epithelium, meninges, bones, and heart found in many mammals and birds. Melanin is a dark pigment primarily responsible for skin color. Once synthesized, mel… See more

    Function

    Through a process called melanogenesis, melanocytes produce melanin, which is a pigment found in the skin,
    There … See more

    Role in the immune system

    In addition to their role as UV radical scavengers, melanocytes are also part of the immune system, and are considered to be immune cells. Although the full role of melanocytes in immune response is not fully unders… See more

    Clinical significance

    • Melanoma - Cancer affecting melanocytes
    • Melanocytic tumors
    • Melanocytic tumors of uncertain malignant potential
    • Vitiligo - Decreased number of melanocytes due to autoimmune destruction causing decreased melanin… See more

    See also

    • Chromatophore (the pigment cell type found in poikilotherm animals)
    • Eye color
    • Mole (skin marking)
    • Tanning activator… See more

    Further reading

    • Ito S (June 2003). "The IFPCS presidential lecture: a chemist's view of melanogenesis". Pigment Cell Research. 16 (3): 230–6. doi:10.1034/j.1600-0749.2003.00037.x. PMID 12753395.
    • Millington … See more

    External links

    • Histology image: 07903loa – Histology Learning System at Boston University - "Eye: fovea, RPE"
    • Histology image: 08103loa – Histology Learning System at Boston University - "Integument: pigmented skin"… See more

     
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  2. Basal layer of epidermis
    • According to 2 sources
    Melanocytes reside in the basal layer of epidermis where they form the epidermal melanin units as a result of the relationship between one melanocyte and 30-40 associated keratinocytes [12]. The ratio of melanocytes to keratinocytes is 1: 10 in the epidermal basal layer (Figure 1).
    Transplant studies in 1940s were the first to report that melanocytes originate from embryonic cells named neural crest cells and migrate into the skin 4,5. The mature melanocytes reside in the basal layer of epidermis, where they approximately constitute every tenth cell.
     
  3. Skin melanocytes: biology and development - PMC

    In the human skin, melanocytes are present in the epidermis and hair follicles. The basic features of these cells are the ability to melanin production and the origin from neural crest cells.

     
  4. Melanocyte | Pigmentation, Skin Color, Melanin | Britannica

  5. What does a Melanocyte do? Definition, Function, Life Cycle

  6. Melanocytes and Their Diseases - PMC - PubMed Central (PMC)

  7. Melanocyte biology and skin pigmentation - Nature

    Feb 21, 2007 · Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They are responsible for the pigmentation of skin and hair, and thereby contribute to the appearance of...

  8. Skin: The Histology Guide - University of Leeds

  9. The Melanocyte: Its Structure, Function, and Subpopulations in …

  10. The Melanocyte: Its Structure, Function, and Subpopulations in …

  11. Melanocyte - an overview | ScienceDirect Topics

  12. Signaling Pathways in Melanogenesis - PMC

    Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones, heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in response to a complex network of interacting …

  13. Melanocyte - an overview | ScienceDirect Topics

  14. Melanocyte – your pigment factory in the skin

  15. Melanocytes | Pathology dictionary - MyPathologyReport.ca

  16. Understanding the Melanocyte Distribution in Human Epidermis: …

  17. Melanocytes - (Anatomy and Physiology I) - Vocab, Definition

  18. Melanocytes and Skin Immunity - Journal of Investigative …

  19. Melanocytes: Definition & Function | Vaia

  20. Regulation of melanocyte stem cells in the pigmentation of skin …

  21. The Skin Atlas - skin.science