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- Neurofilament-light chain (Nf-L) is a non-specific early-stage biomarker widely studied in the context of neurodegenerative diseases (NDD) and traumatic brain injuries (TBI), which can be measured in biofluids after axonal damage.
DOI: 10.3390/ijms241411624Publication: Int J Mol Sci. 2023 Jul; 24(14): 11624.Published: 2023/07www.ncbi.nlm.nih.gov/pmc/articles/PMC10380627/ - People also ask
Neurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter and many micrometers in length. Together with microtubules (~25 nm) and microfilaments (7 nm), they form the neuronal cytoskeleton. They are believed to function primarily to provide structural support for axons and to regulate axon diameter, which influences nerve conduction velocity. The proteins that form neurofilaments are …
Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 12 mins
WEBNeurofilament light (NfL) is the most studied neurofilament in human disease and the most commonly-reported neurofilament in research publications. Since neurofilaments are released from neurons due to …
WEBNeurofilament light chain (NEFL) encodes for one of the three subunits of neurofilaments, which are the major type of intermediate filaments found in neurons. Mutations in NEFL …
WEBFeb 10, 2020 · Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured not only in cerebrospinal fluid but also in serum, which allows for …
- Studies of neurofilament light chain wikipedia
WEBApr 12, 2024 · We then discuss analytical and statistical approaches and challenges in determining neurofilament levels in different clinical contexts and assess the …
WEBJul 19, 2023 · Neurofilament-light chain (Nf-L) is a reliable biomarker in the context of neurodegenerative diseases (NDD) and traumatic brain injuries (TBI). This protein is …
WEBNov 4, 2020 · Neurofilament light chain (NfL), a cytoskeletal protein expressed only in neurons, has emerged as such a biomarker. With the ability to quantify neuronal damage in blood, NfL is being applied to a …
WEBSep 10, 2019 · The value of neurofilament light chain (NfL) as a prognostic blood biomarker in various neurological diseases has been highlighted by three recently …
Serum neurofilament light chain - PMC - National Center for ...
WEBSep 24, 2020 · Neurofilament light chain (NfL) is a promising molecular surrogate marker that indicates neuroaxonal injury in various diseases because it is released into CSF and blood as a subunit of a cytoskeletal protein in case of neuroaxonal damage. 8, 9 In MS, CSF NfL levels correlate with classical relapses and disability. 10, – 12 Recently, the single ...
WEBHere, we review what is known about the structure and function of neurofilaments, discuss analytical aspects and knowledge of age-dependent normal ranges of neurofilaments …
Neurofilament light chain: defining the analyte - PMC
WEBMar 21, 2022 · In 1996, Lars Rosengren, 1 a histologist and neurologist at Sahlgrenska University Hospital, Gothenburg, Sweden, published the first enzyme-linked …
Serum neurofilament light chain | Neurology Neuroimmunology ...
WEBSep 24, 2020 · Neurofilament light chain (NfL) is a promising molecular surrogate marker that indicates neuroaxonal injury in various diseases because it is released into CSF and …
Frontiers | Neurofilament-Light Chain as Biomarker of …
WEBJun 10, 2020 · Neurofilament-light chain (NF-L) is a well-known clinical biomarker of many neurodegenerative diseases. By analyzing amyotrophic lateral sclerosis (ALS) patients …
Neurofilament light chain as a biomarker in neurological disorders
WEBNeurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood …
WEBAXON. NEUROFILAMENTS. Figure 1: Neurofilment light chain is a neuron specific protein that lines the axons of healthy neurons. Areas of Clinical Study for NfL. NNfL has been studied as a neurodegenerative or neuronal injury biomarker in a variety of diseases and conditions,3 including:
The Evolution of Neurofilament Light Chain in Multiple Sclerosis
WEBApr 6, 2021 · Neurofilament Light chain (NfL), a neuron-specific cytoskeletal protein that is released into the extracellular fluid following axonal injury, has been identified as a …
Guidance for use of neurofilament light chain as a cerebrospinal …
WEBNeurofilament light chain (NfL) is a long-awaited blood biomarker that can provide clinically useful information about prognosis and therapeutic efficacy in multiple sclerosis …
Neurofilament light chain as a biomarker in neurological disorders
WEBNeurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood …
Introducing neurofilament light chain measure in psychiatry
WEBMar 19, 2024 · Neurofilament light chain (NfL), a neuron-specific cytoskeletal component released in extracellular matrices after neuroaxonal impairment, is considered a …
The dazzling rise of neurofilaments: Physiological functions and …
WEBFeb 1, 2021 · Figure 1. Neurofilaments (NFs). (a) Composition and domain organization of NF proteins. The NF triplet is composed of the NF-L (light), NF-M (medium) and NF-H …
A map of neurofilament light chain species in brain and …
WEBFeb 22, 2022 · Neurofilament light is a well-established marker of both acute and chronic neuronal damage and is increased in multiple neurodegenerative diseases. However, …
A map of neurofilament light chain species in brain and ... - PubMed
WEBFeb 22, 2022 · Neurofilament light is a well-established marker of both acute and chronic neuronal damage and is increased in multiple neurodegenerative diseases. However, the protein is not well characterized in brain tissue or body fluids, and it is unknown what neurofilament light species are detected by commercial assays and whether additional …
Neurofilament-Light Chain as Biomarker of Neurodegenerative …
WEBJun 11, 2020 · Neurofilament-light chain (NF-L) is a well-known clinical biomarker of many neurodegenerative diseases. By analyzing amyotrophic lateral sclerosis (ALS) patients …
Neurofilament Light Chain as a Biomarker of Global Cognition in ...
WEBMay 17, 2024 · Neurofilament Light Chain (NfL) is a biomarker of axonal injury elevated in mild cognitive impairment (MCI) and Alzheimer’s disease dementia. Blood NfL also …
Serum neurofilament light chain as a prognostic marker of
WEBMay 21, 2024 · Neurofilament light chain (NfL) is a neuron-specific structural protein released into the extracellular space, including body fluids, upon neuroaxonal damage. …
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