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FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · To understand the molecular basis of FANCD2 dimerization and to gain insight into why it did not bind DNA, we determined the …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- Publish Year: 2020
FANCD2–FANCI is a clamp stabilized on DNA by …
WEBFANCD2–FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA. Ubiquitin is …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- DOI: 10.1038/s41594-020-0380-1
- Publish Year: 2020
- Published: 2020/03
FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2–FANCI (D2–I) protein complex is central to this …
- Studies of fancd2 dimerization
The FA Core Complex Contains a Homo-dimeric …
WEBJan 17, 2017 · A transient interaction with FANCC-FANCE-FANCF alters the FANCI-FANCD2 configuration, stabilizing the dimerization interface. …
- Author: Paolo Swuec, Ludovic Renault, Aaron Borg, Fenil Shah, Vincent J. Murphy, Sylvie van Twest, Ambrosius...
- Publish Year: 2017
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · When cross-links are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2–FANCI …
Mechanism, specificity, and function of …
WEBJun 17, 2021 · Recent work suggests that FANCD2 ubiquitination transforms the ID2 complex into a sliding DNA clamp. Further ubiquitination on FANCI does not alter this closed-on-DNA ID2 conformation. …
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WEBNov 28, 2019 · To understand the molecular basis of FANCD2 dimerization and gain insight into why it did not bind DNA, we determined the structure of the FANCD2 …
Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · Here, we find that ubiquitination of FANCD2 acts to increase ID2's affinity for double‐stranded DNA via promoting a large‐scale conformational change in the complex. The resulting complex encircles …
WEBMono-ubiquitination of FANCI-FANCD2 by the Fanconi anemia core complex activates a major DNA interstrand-crosslink repair pathway important for genome stability …
(PDF) Mechanism, specificity, and function of FANCD2-FANCI ...
WEBJun 1, 2021 · Recent work suggests that FANCD2 ubiquitination transforms the ID2 complex into a sliding DNA clamp. Further ubiquitination on FANCI does not alter this …
FANCD2-FANCI is a clamp stabilized on DNA by ... - bioRxiv
WEBNov 28, 2019 · We also find that isolated FANCD2 is a dimer, but it adopts a closed conformation that is unable to bind DNA. When incubated with free FANCI, the FANCD2 …
Structural insight into FANCI-FANCD2 monoubiquitination
WEBOct 26, 2020 · In this review, we summarize these recent advances in the structural and molecular understanding of these key components in the FA pathway, compare the …
The FA Core Complex Contains a Homo-dimeric Catalytic …
WEBJan 17, 2017 · A transient interaction with FANCC-FANCE-FANCF alters the FANCI-FANCD2 configuration, stabilizing the dimerization interface. Our data provide a model …
Structural insight into FANCI–FANCD2 monoubiquitination
WEBJul 29, 2020 · In this review, we summarize these recent advances in the structural and molecular understanding of these key components in the FA pathway, compare the …
The key to the FANCD2–FANCI lock - Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
Mechanism of Ubiquitination and Deubiquitination in the Fanconi …
WEBDec 13, 2016 · As the cycle of FANCD2 monoubiquitination and deubiquitination is critical to the successful repair of DNA interstrand crosslinks, our findings have important …
Structure of the FANCI-FANCD2 Complex: Insights into the …
WEBJul 7, 2011 · The 3.4 Å crystal structure of the ~300 kDa ID complex reveals that monoubiquitination and regulatory phosphorylation sites map to the I-D interface, …
FANCD2 Binds CtIP and Regulates DNA-End Resection during …
WEBMay 22, 2014 · Our results indicate that FANCD2 directly interacts with CtIP, which associates with chromatin in a manner dependent on FANCD2 and its …
FANCD2 maintains replication fork stability during ... - Nature
WEBMay 27, 2022 · Here, we report that the 5-methyl-2’-deoxycytidine (5mdC) demethylation (pathway) intermediate 5-hydroxymethyl-2’-deoxycytidine (5hmdC) and its deamination …
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
FANCI forms a monomer and binds DNA whereas FANCD2 is
WEBTo understand the molecular basis of FANCD2 dimerization and gain insight into why it did not bind DNA, we determined the structure of the FANCD2 homodimer using cryoEM to …
Structural insights into 5′ flap DNA unwinding and incision by the ...
WEBDec 11, 2014 · Here we report three crystal structures of human FAN1 in complex with a 5′ flap DNA substrate, showing that two FAN1 molecules form a head-to-tail dimer to …
MYC multimers shield stalled replication forks from RNA polymerase
WEBNov 23, 2022 · MYC multimers accumulate on chromatin immediately adjacent to stalled replication forks and surround FANCD2, ATR and BRCA1 proteins, which are located at …
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