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  1. Reverse transcriptase - Wikipedia

    • A reverse transcriptase (RT) is an enzyme used to convert RNA genome to DNA, a process termed reverse transcription. Reverse transcriptases are used by viruses such as HIV and hepatitis B to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, and by eukaryotic cells to extend the telomeres a… See more

    History

    Reverse transcriptases were discovered by Howard Temin at the University of Wisconsin–Madison in
    Well … See more

    Function in viruses

    The enzymes are encoded and used by viruses that use reverse transcription as a step in the process of replication. Reverse-transcribing RNA viruses, such as retroviruses, use the enzyme to reverse-transcribe t… See more

    SymbolRVT_1
    Pfam clanCL0027
    InterProIPR000477
    In cellular life

    Self-replicating stretches of eukaryotic genomes known as retrotransposons utilize reverse transcriptase to move from one position in the genome to another via an RNA intermediate. They are found abundantly … See more

    Structure

    The reverse transcriptase employs a "right hand" structure similar to that found in other viral nucleic acid polymerases. In addition to the transcription function, retroviral reverse transcriptases have a domain belonging t… See more

    Replication fidelity

    There are three different replication systems during the life cycle of a retrovirus. The first process is the reverse transcriptase synthesis of viral DNA from viral RNA, which then forms newly made complemen… See more

    Applications

    As HIV uses reverse transcriptase to copy its genetic material and generate new viruses (part of a retrovirus proliferation circle), specific drugs have been designed to disrupt the process and thereby suppress it… See more

     
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  2. Synthesis of DNA from an RNA template
    • According to 2 sources
    Reverse transcription (which occurs in both prokaryotes and eukaryotes) is the synthesis of DNA from an RNA template. A class of RNA viruses, called retroviruses, are characterized by the presence of an RNA‐dependent DNA polymerase (reverse transcriptase).
    Reverse transcription is the synthesis of DNA from an RNA template. This process is driven by RNA-dependent DNA polymerases, also known as reverse transcriptases. Reverse transcriptases occur naturally in both prokaryotic and eukaryotic organisms, as well as in retroviruses. Figure 1.
     
  3. Overview of Reverse Transcription - Retroviruses - NCBI Bookshelf

     
  4. Reverse Transcription Basics | Thermo Fisher Scientific - US

  5. 8.8: Reverse Transcription - Biology LibreTexts

    Mar 21, 2024 · These RNA-encoded viruses have a phase in their life cycle in which their genomic RNA is converted back to DNA by a virally-encoded enzyme known as reverse transcriptase. The ability to convert RNA to DNA is a …

  6. Reverse transcriptase | Enzyme Function & Applications | Britannica

  7. Reverse Transcriptase: From Transcriptomics to …

    Jul 8, 2020 · Reverse transcriptases (RTs) are enzymes that can generate a complementary strand of DNA (cDNA) from RNA. Coupled with PCR, RTs have been widely used to detect RNAs and to clone expressed genes. Classical …

  8. Reverse Transcriptase - an overview | ScienceDirect Topics

  9. Reverse Transcriptase and the Generation of Retroviral DNA

  10. Reverse Transcriptase - an overview | ScienceDirect Topics

  11. Reverse Transcription - an overview | ScienceDirect Topics

  12. Reverse Transcriptase - Detailed Overview, Uses and …

  13. HIV-1 Reverse Transcription - PMC - PubMed Central (PMC)

  14. Reverse Transcriptases: From Discovery and Applications to

  15. Reverse Transcription Technology - Life Science

  16. Difference Between Transcription and Reverse Transcription

  17. Reverse Transcription - CliffsNotes

  18. Reverse Transcription - an overview | ScienceDirect Topics

  19. Reverse Transcriptase & cDNA Overview & Applications - GoldBio

  20. Reverse Transcription - MilliporeSigma

  21. Reverse Transcription - an overview | ScienceDirect Topics

  22. An atlas of transcription initiation reveals regulatory principles of ...

  23. A Brief Review of Short Tandem Repeat Mutation - PMC