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- The pain of mild sickle-cell crises is managed with paracetamol, a NSAID, codeine phosphate, or dihydrocodeine tartrate. Severe crises may require the use of morphine or diamorphine hydrochloride; concomitant use of a NSAID may potentiate analgesia and allow lower doses of the opioid to be used.bnf.nice.org.uk/treatment-summaries/analgesics/
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