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- Fever is a result of raising the hypothalamic set point, triggering vasoconstriction and shunting of blood from the periphery to decrease heat loss1. It is generally triggered by exogenous pyrogens such as bacteria, viruses, and toxins, which interact with macrophages or monocytes, resulting in cytokine induction within 2 hours of exposure2.Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.Normally, the hypothalamic thermoregulatory center maintains the internal temperature between 37 ° and 38 ° C. Fever results when something raises the hypothalamic set point, triggering vasoconstriction and shunting of blood from the periphery to decrease heat loss; sometimes shivering, which increases heat production, is induced.www.msdmanuals.com/professional/infectious-dise…The pathophysiology of Fever is generally triggered by exogenous pyrogens (for instance, bacteria, viruses, toxins) through interaction with macrophages or monocytes, which result in cytokine induction within 2 hours of exposure.www.dailyhumancare.com/fever-and-pathophysiolo…
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