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  2. Normally, the hypothalamic thermoregulatory center maintains the internal temperature between 37 ° and 38 ° C. Fever results when something raises the hypothalamic set point, triggering vasoconstriction and shunting of blood from the periphery to decrease heat loss; sometimes shivering, which increases heat production, is induced.
    www.msdmanuals.com/professional/infectious-dise…
    The pathophysiology of Fever is generally triggered by exogenous pyrogens (for instance, bacteria, viruses, toxins) through interaction with macrophages or monocytes, which result in cytokine induction within 2 hours of exposure.
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