The term protein family has broad usage and can be applied to large groups of proteins with barely detectable sequence similarity as well as … See more

According to current consensus, protein families arise in two ways. First, the separation of a parent species into two genetically isolated descendant species allows a gene/protein to independently accumulate variations (mutations) in these two lineages. This … See more

Many biological databases catalog protein families and allow users to match query sequences to known families. These include: See more

• Gene family
• Genome annotation
• Sequence clustering
Protein families See more

Protein families were first recognised when most proteins that were structurally understood were small, single-domain proteins such as myoglobin, hemoglobin, and cytochrome c. Since then, many proteins have been found with multiple independent … See more

As the total number of sequenced proteins increases and interest expands in proteome analysis, an effort is ongoing to organize proteins into families and to describe their component domains and motifs. Reliable identification of protein families is critical to See more

• Media related to Protein families at Wikimedia Commons See more