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  1. Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A …

    • We enrolled 338 adults, 51.8% of whom were men. The least-squares mean percentage change in body weight at 24 weeks in the retatrutide groups was −7.2% in the 1-mg group, −12.9% in the combiSee more

    Background

    Retatrutide (LY3437943) is an agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors. Its dose–response relationship… See more

    The New England Journal of Medicine
    Methods

    We conducted a phase 2, double-blind, randomized, placebo-controlled trial involving … See more

    The New England Jour…
    Conclusions

    In adults with obesity, retatrutide treatment for 48 weeks resulted in substantial reductions in body weight. (Funded by Eli Lilly; ClinicalTrials.gov number, NCT04881… See more

    The New England Journal of Medicine
    Trial Design

    We conducted this phase 2, multicenter, randomized, double-blind, placebo-controlled trial in the United States (see the Supplementary Appendix, available with the full text of t… See more

    The New England Journal of Medicine
    Participants

    Persons who were 18 to 75 years of age and either had a body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) of 30 to 50 or had a BMI of 27 t… See more

    The New England Journal of Medicine
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  2. In people with type 2 diabetes, retatrutide showed clinically meaningful improvements in glycaemic control and robust reductions in bodyweight, with a safety profile consistent with GLP-1 receptor agonists and GIP and GLP-1 receptor agonists. These phase 2 data also informed dose selection for the phase 3 programme.
    www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01053-X/fulltext
    www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01053-X/fulltext
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  7. Triple hormone receptor agonist retatrutide for metabolic ... - Nature

  8. Retatrutide, a GIP, GLP-1 and glucagon receptor …

    Retatrutide, a single peptide with agonist activity at the glucose-dependent insulinotropic polypeptide (GIP), GLP-1, and glucagon receptors, showed clinically meaningful glucose-lowering and bodyweight-lowering efficacy in …

  9. Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A …

  10. Triple–Hormone-Receptor Agonist Retatrutide for Obesity

  11. American Diabetes Association Highlights Novel Agent …

  12. ESC 2024: Retatrutide improves lipid and …

    4 days ago — This morning at the European Society of Cardiology (ESC) Congress 2024, Eli Lilly and Co announced the most recent trial results for retatrutide related to cardiovascular risk factors.

  13. Triple Agonist Retatrutide Associated with Weight …

    Jun 27, 2023 — Lilly’s Phase 2 retatrutide results published in the New England Journal of Medicine show the investigational molecule achieved up to 17.5% mean weight reduction at 24 weeks in adults with obesity and overweight.

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  18. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for …

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  20. The Lancet study unveils exciting findings on retatrutide as a …

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  25. Phase 2 Trial of Retatrutide for Obesity - The New England …

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