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- After transcription, mRNA undergoes crucial modifications: the addition of a 7-methylguanosine (m 7 G) cap at the 5' end, a polyadenylation tail at the 3' end, and splicing to remove introns. The poly-A tail, triggered by the polyadenylation signal (AAUAAA), aids in nuclear export.
www.pearson.com/channels/genetics/learn/kylia/transcription/rna-modification-a… RNA processing and modifications - Nature
Oct 21, 2024 · Specialized RNA modification sequencing techniques are helping to uncover how dysregulation of RNA modification leads to disease.
See results only from nature.comAbout our series | RNA proc…
It has become clear that the different steps of pre-mRNA processing, from 5' …
Regulation of microRNA b…
We then discuss the interplay between RNA-binding proteins (RBPs) and …
RNA processing and its re…
This study uses RNA–seq and bioinformatics analyses to investigate …
RNA modification - Latest re…
RNA modifications are changes to the chemical composition of ribonucleic acid …
RNA modifications in physiol…
In this Review, we describe the molecular and cellular functions of chemical …
RNA editing - Wikipedia
RNA editing (also RNA modification) is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated by RNA polymerase. It occurs in all living organisms and is one of the most evolutionarily conserved properties of RNAs. RNA editing may include the insertion, deletion, and base substitution of nucle…
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Importance and Impacts of RNA Modifications in …
Jul 22, 2024 · RNA modifications have broad impacts on gene expression and regulate processes that impact development, stress response, health, and disease (Roundtree et al., 2017). The addition and removal of RNA …
RNA processing and its regulation: global insights into …
This study uses RNA–seq and bioinformatics analyses to investigate potential mechanisms by which RNA processing events are coordinately regulated in different tissues.
Synthesis and Processing of RNA - Genomes - NCBI …
We begin our detailed study of transcription by looking at the synthesis and processing of mRNAs, the molecules that make up the transcriptome and which specify the protein content of the cell.
RNA modification: mechanisms and therapeutic targets
Aug 24, 2023 · RNA modifications are dynamic and reversible chemical modifications on substrate RNA that are regulated by specific modifying enzymes. They play important roles in …
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Roles of RNA Modifications in Diverse Cellular Functions
At the cellular level, RNA modifications regulate several cellular processes including cell death, proliferation, senescence, differentiation, migration, metabolism, autophagy, the DNA damage response, and liquid-liquid phase …
RNA Processing and Turnover - The Cell - NCBI Bookshelf
Most newly synthesized RNAs must be modified in various ways to be converted to their functional forms. Bacterial mRNAs are an exception; as discussed earlier in this chapter, they …
Human Mitochondrial RNA Processing and …
Despite substantial progress that has been made in the field of mtRNA processing and its regulation, many unknowns and controversies remain. The present review discusses the current state of knowledge of RNA processing in human …
Dynamic RNA modifications in gene expression regulation
Chemical modifications in RNA affect the transcripts by altering charge, base pairing potential, secondary structure and protein-RNA interactions. These properties in turn shape the outcome …
RNA processing and modifications - Nature
Oct 21, 2024 · Specialized RNA modification sequencing techniques are helping to uncover how dysregulation of RNA modification leads to disease.
Understanding RNA modifications: the promises and …
May 31, 2017 · Here, we review some of the technological advances in this rapidly developing field, identify the conceptual challenges and discuss approaches that are needed to rigorously …
RNA modifications in physiology and pathology: Progressing …
Sep 1, 2024 · We systematically elucidated the mechanisms by which RNA modifications control basic cellular activities in advanced organisms. we delineated the molecular and cellular roles …
About our series | RNA processing and modifications - Nature
Dec 19, 2024 · It has become clear that the different steps of pre-mRNA processing, from 5' capping to nuclear export, are tightly co-regulated and coordinated with transcription, …
RNA Processing - an overview | ScienceDirect Topics
RNA processing mechanisms include cutting, splicing, base modification, and addition of extra nucleotides. Ribosomal and transfer RNA are derived from their primary transcripts by cutting …
RNA Processing - an overview | ScienceDirect Topics
All classes of RNA are subject to processing by base modification and cleavage. In addition, eukaryotic mRNA undergoes capping and tailing as well as splicing (Fig. 12.01). Base …
RNA dysregulation in neurodegenerative diseases | The EMBO …
Jan 9, 2025 · These modifications are reversible and play important roles in various steps of RNA processing regulation (Roundtree et al, 2017). Lately, pathological aberrant RNA modifications …
RNA modifications in cancer - Wu - 2025 - Wiley Online Library
Jan 10, 2025 · RNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6-methyladenosine (m 6 A) and 5 …
RNA modification - Latest research and news | Nature
Jan 11, 2025 · RNA modifications are changes to the chemical composition of ribonucleic acid (RNA) molecules post-synthesis that have the potential to alter function or stability. An …
Human Mitochondrial RNA Processing and Modifications: Overview
Apr 4, 2000 · The present review discusses the current state of knowledge of RNA processing in human mitochondria and sheds some light on the unresolved issues. Keywords: RNA decay; …
RNA Modification and Processing Explained: Definition, Examples ...
Master RNA Modification and Processing with free video lessons, step-by-step explanations, practice problems, examples, and FAQs. Learn from expert tutors and get exam-ready!
tRNA Modifications: Key Roles in Protein Synthesis and Gene …
1 day ago · Transfer RNA (tRNA) modifications have emerged as important elements in protein synthesis and gene regulation. These chemical alterations to tRNA molecules are not mere …
RNA modifications in physiology and disease: towards clinical
Sep 15, 2023 · In this Review, we describe the molecular and cellular functions of chemical modifications found in mRNA, tRNA and rRNA that link transcription with translational output, …
Bridge RNAs: ‘Holy Grail’ in Next-Gen Gene Editing Tech? - WebMD
4 days ago · The breakthrough discovery of a powerful new gene editing tool called bridge RNAs has the potential to significantly advance gene therapy and usher in a new frontier in genome …
Engineering a DNA polymerase for modifying large RNA at …
Jan 13, 2025 · The synthesis of large RNA with precise modifications at specific positions is in high demand for both basic research and therapeutic applications, but efficient methods are …
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