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In parallel with the efforts to establish the nature of the genetic code and the decoding process, it was determined that the amino acid sequence of a protein contains the protein folding code, …

RNA folding is the most essential process underlying RNA function. While significant progress has been made in understanding the forces driving RNA folding in vitro, exploring the rules …

In this review, we discuss switches for RNA folding and function induced by naturally occurring RNA-protein interactions. The conformational flexibility of RNA is also the basis for the RNA …

Apr 5, 2005 · RNA and protein folding mechanism can be described by the kinetic partitioning mechanism (KPM) according to which a fraction (Phi) of molecules reaches the native state …

Feb 7, 2025 · These mRNA transcripts then serve as the template for protein synthesis, a process known as translation. While the core process of translation is conserved across all organisms, …

Sep 24, 2017 · In this paper, we focus on protein folding within the cell, with emphasis on the contribution of the translation machinery and the population of tRNA to this process. The …

From the perspective of an RNA strand, a protein could be a useful tool to facilitate its folding through specific binding or nonspecific (predominantly electrostatic) association. There are …

This modified pre-mRNA molecule then undergoes the process of RNA splicing. Genes are composed of a series of introns and exons, ... When protein folding into the mature, functional …

Protein folding, a process that underpins cellular activity, begins co-translationally on the ribosome. During translation, a newly synthesized polypeptide chain enters the ribosomal exit …

In the cell, most proteins have their first opportunity to fold during their synthesis via translation. Protein synthesis occurs orders of magnitude slower than the rate of formation of α-helices …

Sep 30, 2022 · Utilizing proteins as dynamic RNA folding chaperones could allow advantageous modularity, allowing the RNA sequence to develop into highly specialized final structural states …

Protein folding is therefore the final part of gene expression after transcription, RNA‐processing and translation. Protein folding processes are often, but not always, linked to translation …

Dec 15, 2016 · These findings suggest a model in which the mRNA structure, particularly exceptionally stable RNA structural elements, act as gauges of protein co-translational folding …

The carbohydrate moieties of glycoproteins play important roles in protein folding in the endoplasmic reticulum, in the targeting of proteins for delivery to the appropriate intracellular …

In this review, we break from this format as we cover a more mature scientific area, RNA folding, and we describe general insights drawn from RNA’s molecular behavior and glean lessons …

In this review, we break from this format as we cover a more mature scientific area, RNA folding, and we describe general insights drawn from RNA’s molecular behavior and glean lessons …

Nov 1, 2010 · RNA folding is the most essential process underlying RNA function. While significant progress has been made in understanding the forces driving RNA folding in vitro, exploring the …

Jul 16, 2008 · Studies on in vitro refolding in the presence of RNA, coexpression of RNA molecules in vivo and the mutants with impaired RNA binding ability suggests that RNA can …

Feb 8, 2025 · These mutations influence the timing of translation and co-translational folding of proteins. The speed at which a ribosome moves along an mRNA strand can affect protein …

4 days ago · “Protein folding, and how well we maintain this process, is fundamental to pretty much every disease. But so far, we look at these diseases as separate end points, treating the …

3 days ago · As a result, users should exercise caution when using AlphaFold3 predictions as hypotheses generators for RNA and protein-RNA complex structures. In the interim, …