Roman Reigns and Brock Lesnar have clashed several times over the WWE World Heavyweight Championship and the WWE Universal Championship, with both men trading victories and defeats at major events such as WrestleMania, SummerSlam, and Royal Rumble. Their feud is considered one of the most intense and physical in WWE history.
Roman Reigns faced The Undertaker at WrestleMania 33 in a No Holds Barred match, where he became only the second person to defeat The Undertaker at WrestleMania, after Brock Lesnar. This match is widely regarded as The Undertaker's retirement match, and Roman Reigns received a lot of backlash from the fans for ending his legendary career. Their feud continued briefly in 2019, when they teamed up against Shane McMahon and Drew McIntyre at Extreme Rules.
Roman Reigns and John Cena faced each other at No Mercy 2017, in a highly anticipated match that was billed as a dream match and a passing of the torch. Roman Reigns defeated John Cena, who praised him after the match and handed him the ring. Their feud reignited in 2021, when John Cena challenged Roman Reigns for the WWE Universal Championship at SummerSlam, after returning from a long hiatus.
Roman Reigns and Braun Strowman had a brutal feud in 2017, that saw them attack each other with various weapons, vehicles, and structures. They fought in several stipulation matches, such as an ambulance match, a last man standing match, and a steel cage match, with both men showing incredible resilience and strength. Their feud ended when Roman Reigns defeated Braun Strowman in a hell in a cell match, after interference from Brock Lesnar.
Roman Reigns and Seth Rollins were former allies and members of The Shield, a dominant faction in WWE. Their friendship turned into a bitter rivalry when Seth Rollins betrayed The Shield and joined The Authority, a heel group led by Triple H. Seth Rollins and Roman Reigns fought over the WWE World Heavyweight Championship, with Seth Rollins cashing in his Money in the Bank contract at WrestleMania 31 to steal the title from Roman Reigns. They also had a brief reunion as The Shield in 2017 and 2018, before turning on each other again in 2019.