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FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism …
FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- Publish Year: 2020
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation …
DNA requirement in FANCD2 deubiquitination by USP1-UAF1
WEBJun 28, 2019 · These results help establish that monoubiquitination and deubiquitination of FANCD2 occur sequentially on DNA, implicate RAD51AP1 in the FA pathway of DNA …
DNA clamp function of the monoubiquitinated Fanconi …
WEBMar 11, 2020 · Cryo-EM structures of the FANCI–FANCD2 complex bound to DNA reveal that monoubiquitination triggers structural changes that enable the complex to function as a sliding DNA clamp and...
The key to the FANCD2–FANCI lock - Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
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FANCD2 modulates the mitochondrial stress response to prevent …
WEBJan 29, 2021 · A bioinformatic analysis to identify DNA motifs enriched at FANCD2 genomic binding sites revealed a significant enrichment of mitochondrial UPR response element 1 …
Structure of the FA core ubiquitin ligase closing the ID …
WEBMar 8, 2021 · Cryo-EM structures of the Fanconi anemia core complex reveal insights into the remodeling of the FANCI–FANCD2 DNA clamp, which is essential during the repair of DNA interstrand crosslinks.
In vivo analysis of FANCD2 recruitment at meiotic …
WEBJan 9, 2020 · By employing an amino-terminal tag of CeFANCD2, we showed in vivo that FCD-2 localization is dynamic during prophase I and requires its partner FANCI-1 to load onto DNA, raising the possibility...
WEBFocus and persistence: how Pol IV unblocks stalled DNA synthesis Author: Julian E. Sale Subject: Nature Structural & Molecular Biology, doi:10.1038/s41594-022-00825-4 …
Ubiquitilated Fanconi ID complex embraces DNA | Cell Research
WEBMay 29, 2020 · FANCI competes with one FANCD2 monomer allowing the formation of a stable-open-ID complex that can bind to DNA (Fig. 1). This implicates the FANCD2 …
Fanconi anaemia pathway mechanism surveys DNA and …
WEBThe Fanconi anaemia pathway repairs DNA crosslinks that block DNA replication, and the FANCD2–FANCI (D2–I) protein complex is central to this process as it initiates repair by …
WEBinsight into the human FANCD2–FANCI complex by obtaining the cryo-EM structure. The complex contains an inner cavity, large enough to accommodate a double-stranded DNA
The Fanconi anemia core complex promotes CtIP-dependent end …
WEBAug 16, 2024 · The FA core complex recognizes crosslinked DNA and subsequently ubiquitinates the FANCD2/FANCI heterodimer 18. This is an essential step to recruit …
Methodology for the identification of small molecule inhibitors of …
WEBMay 14, 2020 · FANCD2 mono-ubiquitination leads to the recruitment of DNA repair proteins to the site of the ICL. The loss of FANCD2 mono-ubiquitination is a common …
Fancd2 in vivo interaction network reveals a non-canonical role in ...
WEBApr 5, 2017 · Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 …
The FANCD2–FANCI complex is recruited to DNA interstrand
WEBJul 13, 2016 · FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2 …
FANCI plays an essential role in spermatogenesis and regulates …
WEBAug 9, 2021 · FANCI is an essential component of Fanconi anemia pathway, which is responsible for the repair of DNA interstrand cross-links (ICLs). As an evolutionarily …
The Fanconi anaemia pathway: new players and new functions
WEBMay 5, 2016 · An attractive possibility is that FANCD2 binds to ssDNA arising from MRE11-mediated DNA resection. The function of FANCD2 in protecting nascent DNA strands …
FANCI phosphorylation functions as a molecular switch to turn on …
WEBOct 19, 2008 · In response to DNA damage or replication fork stress, the Fanconi anemia pathway is activated, leading to monoubiquitination of FANCD2 and FANCI and their …
FANCI is a second monoubiquitinated member of the Fanconi
WEBApr 25, 2007 · Activation of the Fanconi anemia (FA) DNA damage–response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core …
FANCD2 promotes mitotic rescue from transcription-mediated
WEBDec 21, 2022 · FANCD2 promotes MUS81 and XPF-dependent cleavages and rescue of un-replicated DNA structures by mitotic DNA synthesis (MiDAS), which allows sister …
Inactivation of ribosomal protein S27-like impairs DNA ... - Nature
WEBOct 13, 2020 · Here we identified that RPS27L binds to FANCD2 and FANCI, two Fanconi anemia (FA) proteins functioning in ICL repair pathway.
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