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SLAMF1 - Wikipedia
Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene. Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150). SLAMF1 belongs to the signaling lymphocytic activation molecule family. As other receptors from this family, SLAMF1 is … See more
The gene encoding SLAMF1 receptor is located on the human chromosome 1. It consists of eight exons and seven introns. Alternative splicing of SLAMF1 transcripts results in several See more
SLAMF1 is a type I transmembrane protein belonging to the immunoglobulin superfamily. Its molecular weight is between 70 kDa and … See more
SLAMF1 is involved in the regulation of thymocyte development, T cell proliferation, differentiation and T cell function, such as the cytotoxic activity of CD8+ T cells and the production of IL-4, IL-13 and IFNÎł. In B cells, it regulates the proliferation and the See more
• Punnonen J, Cocks BG, Carballido JM, Bennett B, Peterson D, Aversa G, de Vries JE (March 1997). "Soluble and membrane-bound forms of … See more
Viral infections
SLAMF1 is a receptor for Morbilliviruses. This genus of viruses includes agents causing measles in humans, rinderpest in cattle and distemper in dogs and cats. Ig variable-like domain of SLAMF1 binds to hemagglutinin See moreWikipedia text under CC-BY-SA license SLAMF1 Gene - GeneCards | SLAF1 Protein | SLAF1 …
Dec 25, 2024 · SLAMF1 is a protein coding gene that belongs to the signaling lymphocytic activation molecule family. It is involved in various immune functions and diseases, and has different signaling pathways and modes depending on …
SLAMF Receptors: Immune Regulators in Health and …
The signaling lymphocyte activation molecule family (SLAMF) of cell surface receptors, which consists of nine transmembrane proteins (SLAMF1-9) expressed at different levels, are involved in viral and bacterial recognition, serve as co …
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SLAMF1 - an overview | ScienceDirect Topics
SLAMF1 is a member of the SLAM family of receptors that regulates immune and inflammatory responses. Learn about its structure, signaling, expression and role in hematological …
Frontiers | Identification of SLAMF1 as an immune-related key …
SLAM-family receptors come of age as a potential molecular …
SLAMF1 extracellular domain is a measles virus receptor, and SLAMF1 functions as a co-stimulator on T and B cells. Although type 1 T helper (Th1) cells have significant levels of …
SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent …
Apr 2, 2018 · In this study, we report that SLAMF1 is required for Toll-like receptor 4 (TLR4)-mediated induction of interferon β (IFNβ) and for killing of Gram-negative bacteria by human …
Slamf1 signaling lymphocytic activation molecule family member 1 ...
Feb 8, 2025 · Slamf1 is a bacterial sensor that regulates intracellular enzyme activities involved in the removal of Gram-negative bacteria. SLAM signaling drives most of (interleukin) IL-4 …
The SLAM family receptors: potential therapeutic targets for ...
The signaling lymphocytic activation molecule (SLAM) family is comprised of nine distinct receptors (SLAMF1 through SLAMF9) that are expressed on hematopoietic cells. All of these …
SLAMF receptors negatively regulate B cell receptor signaling in ...
Aug 21, 2020 · Overexpression of SLAMF1 or SLAMF7 in IGHV mutated CLL cell models resulted in reduced proliferation and impaired responses to BCR ligation, whereas the knockout of both …
SLAMF1 as a novel molecule mediating the causal association …
Dec 5, 2024 · Our correlation analysis reveals a positive association between SLAMF1 expression and IL-4 and IL-13 levels in lung tissues from pulmonary fibrosis patients, suggesting that …
SLAMF Receptor Expression Identifies an Immune Signature That ...
May 6, 2022 · Several studies have shown that signaling lymphocytic activation molecule family (SLAMF) receptors are aberrantly expressed and dysfunctional in SLE immune cells, …
The SLAM family receptors: Potential therapeutic targets for
The signaling lymphocytic activation molecule (SLAM) family is comprised of nine distinct receptors (SLAMF1 through SLAMF9) that are expressed on hematopoietic cells. All of these …
SLAMF1 signaling lymphocytic activation molecule family …
Identification of SLAMF1 as an immune-related key gene associated with rheumatoid arthritis and verified in mice collagen-induced arthritis model. SLAMF1 is expressed and secreted by …
Q13291 - UniProt
SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps …
Slamf1, the NKT Cell Control Gene Nkt11 - American Association …
Feb 1, 2007 · Slamf1 encodes the Ig-like receptor termed SLAM or CD150, which forms homotypic interactions and modulates immune responses (17, 23).
Receptor signaling lymphocyte-activation molecule family 1 …
May 25, 2012 · This Slamf1/Beclin-1/Vps34/UVRAG protein complex is formed in intracellular membrane compartments as it is found without inducing phagocytosis in macrophages, human …
JCI - SLAMF1 regulation of chemotaxis and autophagy …
Nov 30, 2015 · Here, we have shown that expression of the costimulatory molecule and microbial sensor SLAMF1 (also known as CD150) is lost in a subset of patients with an aggressive CLL …
Q9QUM4 - UniProt
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation …
SLAMF1 - Abcam
SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps …
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