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Nature
https://www.nature.com › articles
The prognostic and immune significance of SLAMF9 in pan …
Cell-based assays demonstrated that SLAMF9 knockdown attenuated the proliferative, motile, and invasive capacities of colorectal cancer (CRC) cells. In a nude mouse xenograft model, suppression...
Is slamf9 expression associated with tumor purity?
Through the analysis of over 40 frequently occurring immune checkpoint genes, we identified a correlation between SLAMF9 expression and tumor purity, as well as an inverse relationship with TIICs, which suggests an association between SLAMF9 expression and tumor infiltration levels.
nature.com
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The Five Stages of Prostate Cancer | Prostate Cancer Staging Guide
YouTubeProstate Cancer Research Institute173.9K viewsAug 14, 2018
The novel immunoglobulin super family receptor SLA…
The study was performed according to federal laws and regulations as well as institutional policies. We obtained ethical approval from the local ethical committee (reference number: 2010-318N-MA). Written informed consent was obtained from all patients and data were analyzed anonymously.
Nature
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C57BL/6 were purchased from The Jackson Laboratory. All mice were housed under specific pathogen-free conditions at the animal facility Mannheim. Animal experimental protocols were approved by the animal ethics committee (Regierungspräsidium Karlsruhe, Az: 35-9185.81/G-42/14)
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The human monocytic cell line U937 (CRL-1593.2™, ATCC®, Wesel, Germany) and the human melanoma cell line WM115 (CRL-1675™, ATCC®, Wesel, Germany) were cultured in RPMI-1640 (Gibco by Thermo Fisher Scientific, Darmstadt, Germany) supplemented with 10% fetal calf serum (FCS, Biochrom, Berlin, Germany), 100 U penicillin, as well as 100 mg/l streptomyc...
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The respective tumor cell line was allowed to reach 50% confluency. Medium was removed and the monolayer was washed once with PBS (Gibco by Thermo Fisher Scientific, Darmstadt, Germany). New culture medium was added and incubated with the cells for 48 h at 37 °C and 5% CO2. Thereafter, the conditioned cell culture medium was collected and centrifug...
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A total of 1 × 106 B16F1 cells were injected subcutaneously into the flank of 8–10 weeks old female mice. After 14 days of tumor growth, mice were sacrificed and the excised tumors were further processed for CD11b+cells isolation.
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Mouse insertional mutagenesis experiments DO NOT support the designation of SLAMF9 as a cancer causing gene. This gene does not have a cancer hallmark. You can see more information about hallmarks. See all drug sensitivity data for SLAMF9.
SLAMF9 Gene - Somatic Mutations in Cancer - Wellcome Sanger …
cancer.sanger.ac.uk/cosmic/gene/analysis?ln=SLAMF9
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
The prognostic and immune significance of SLAMF9 in pan …
Cell-based assays demonstrated that SLAMF9 knockdown attenuated the proliferative, motile, and invasive capacities of colorectal cancer (CRC) cells. In a nude mouse xenograft model, …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
SLAM-family receptors come of age as a potential molecular …
There is growing evidence that SLAM-family receptors have been involved in cancer progression and heralded as a novel immune checkpoint on T cells.
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
SLAM Modification as an Immune-Modulatory Therapeutic …
This review delves into the roles of specific SLAM members, such as SLAMF8 and SLAMF9, and their impact on tumor progression in cancers like colorectal cancer and melanoma. Recent …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
The novel immunoglobulin super family receptor SLAMF9 …
Sep 19, 2018 · In a subcutaneous ovarian cancer model, it has been demonstrated that the injection of IFN-γ into the tumor induced the expression of Programmed Death Ligand 1 (PD …
PubMed
https://pubmed.ncbi.nlm.nih.gov
The prognostic and immune significance of SLAMF9 in pan …
Aug 2, 2024 · Cell-based assays demonstrated that SLAMF9 knockdown attenuated the proliferative, motile, and invasive capacities of colorectal cancer (CRC) cells. In a nude mouse …
American Association for Cancer Research
https://aacrjournals.org › cancerres › article
Abstract 1371: SLAMF9 promotes tumor progression and …
Mar 22, 2024 · Signaling lymphocytes activating molecule factors (SLAMFs) has been reported to play a key role in regulating tumor immunity. Herein, using multi cohorts, in vitro and in vivo …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Signatures of H3K4me3 modification predict cancer ... - PubMed
Jan 15, 2025 · The mice melanoma model showed Slamf9 knockdown remarkably restrained cancer progression and enhanced the efficacy of anti-CTLA-4 and anti-PD-L1 therapies by …
Nature
https://www.nature.com › articles
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The prognostic and immune significance of SLAMF9 in pan …
Feb 18, 2024 · Cell‐based assays demonstrated that SLAMF9 knockdown attenuated the proliferative, motile, and invasive capacities of colorectal cancer (CRC) cells. In a nude mouse …
Research Square
https://www.researchsquare.com › article
The prognostic and immune significance of SLAMF9 in pan …
Through systematic pan-cancer analysis, we demonstrated that SLAMF9 expression was increased in a variety of tumor tissues, and that overexpression of this protein may lower …
PubMed
https://pubmed.ncbi.nlm.nih.gov
SLAMF9 regulates pDC homeostasis and function in health and …
Aug 13, 2019 · Analysis of pDCs in SLAMF9 -/- mice revealed an increase of immature pDCs in the bone marrow and enhanced accumulation of pDCs in the lymph nodes. In the periphery, …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
The SLAM family receptors: potential therapeutic targets for ...
This study also suggested that the upstream binding partner SLAMF6 is a potential target in cancer immunotherapy, allowing NK cells to act on both hematopoietic and non-hematopoietic …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
The prognostic and immune significance of SLAMF9 in pan …
Aug 2, 2024 · In the TCGA data, SLAMF9 was found to be significantly upregulated in 16 of 20 cancer types, except in cholangiocarcinoma (CHOL), esophageal carcinoma (ESCA), …
SSRN
https://papers.ssrn.com › papers.cfm
Signatures of H3K4me3 Modification Predict Cancer …
Apr 13, 2023 · SLAMF9 was the underlying determinant of high H3K4me3-RS-linked immunosuppressive phenotype and immunotherapy resistance in cancers. Slamf9 knockdown …
MDPI
https://www.mdpi.com
SLAM Modification as an Immune-Modulatory Therapeutic …
Sep 29, 2023 · In the dynamic realm of cancer research, the Signaling Lymphocyte Activation Molecule (SLAM) family has emerged as a significant factor in modulating immune responses …
Respiratory Research
https://respiratory-research.biomedcentral.com › articles
Signatures of H3K4me3 modification predict cancer …
Jan 15, 2025 · The mice melanoma model showed Slamf9 knockdown remarkably restrained cancer progression and enhanced the efficacy of anti-CTLA-4 and anti-PD-L1 therapies by …
sanger.ac.uk
https://cancer.sanger.ac.uk › cosmic › gene › analysis
SLAMF9 Gene - Somatic Mutations in Cancer - Wellcome Sanger …
Mouse insertional mutagenesis experiments DO NOT support the designation of SLAMF9 as a cancer causing gene. This gene does not have a cancer hallmark. You can see more …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
SLAMF9 regulates pDC homeostasis and function in health and …
SLAMF9 −/− mice demonstrated attenuated disease and delayed onset, accompanied by a prominent increase of immature pDCs in the lymph node, with a reduced costimulatory …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Signatures of H3K4me3 modification predict cancer …
Public data analysis and in vivo experiments validated that tumor Slamf9 regulated CD8 + T cell infiltration and PD-1 expression within TME, and Slamf9 deficiency significantly sensitized …

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