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  1. Nature
    https://www.nature.com › articles

    Small-cell lung cancer | Nature Reviews Disease Primers

    • Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by an exceptionally high proliferative rate, strong predilection for early metastasis and poor prognosis. SCLC is strongl… See more

    Introduction

    Small-cell lung cancer (SCLC) is a high-grade neuroendocrine carcinoma arising … See more

    Nature
    Epidemiology

    Incidence and prevalence
    Lung cancer is the leading cause of cancer mortality worldwide, with an estimated 2.1 million new cases and 1.8 million deaths in 2018 (ref.4)… See more

    Nature
    Mechanisms/pathophysiology

    SCLC tumour mutational profiling reveals a clear smoking signature, providing direct evidence that tobacco carcinogens are responsible for the initiation of SCLC24. Concomita… See more

    Nature
    Diagnosis, screening and prevention

    SCLC is a high-grade malignant epithelial tumour. A confirmed diagnosis relies on characteristic light microscopic features of the tumour with haematoxylin and eosin staining (hi… See more

    Nature
    Management

    The initial approach to SCLC treatment varies substantially by stage (Fig. 5). In non-metastatic SCLC, the goals of treatment include achieving durable control of thoracic … See more

    Nature
    Is there a future for small-cell lung cancer?
    Thus, while the past has been bleak, the future offers greater promise. Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung cancers and is pathologically, molecularly, biologically and clinically very different from other lung cancers.
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    Table of Contents
    Introduction
    Epidemiology
    Mechanisms/pathophysiology
    Diagnosis, screening and prevention
    Management
    Is there a future for small-cell lung cancer?
     

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  2. Nature
    https://www.nature.com › articles

    Small-cell lung cancer: what we know, what we need …

    Dec 1, 2017 · Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung cancers and is pathologically, molecularly, biologically and clinically very different from other...

     
  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › books

    Small Cell Lung Cancer - StatPearls - NCBI Bookshelf

    Jul 10, 2023 · This activity reviews the cause, pathophysiology and presentation of small cell lung cancer and highlights the role of the interprofessional team in its management. Objectives: Describe the pathophysiology of small cell lung …

  4. JAMA Network
    https://jamanetwork.com › journals › jamaoncology › fullarticle

    Emerging Strategies for Small Cell Lung Cancer Treatment

  5. Mayo Clinic Proceedings
    https://www.mayoclinicproceedings.org › a…

    Current Diagnosis and Management of Small-Cell …

    Aug 2, 2019 · Small-cell lung cancer (SCLC) is an aggressive disease with distinct pathological, clinical, and molecular characteristics from non–small-cell lung cancer. SCLC has high metastatic potential, resulting in a clinically poor …

  6. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Small-cell lung cancer - PMC - PubMed Central (PMC)

  7. People also ask
    What is the prognosis of small-cell lung cancer (SCLC)?
    Nature Reviews Disease Primers 7, Article number: 3 (2021) Cite this article Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by an exceptionally high proliferative rate, strong predilection for early metastasis and poor prognosis. SCLC is strongly associated with exposure to tobacco carcinogens.

    Small-cell lung cancer | Nature Reviews Disease Primers

    nature.com
    What is small-cell lung cancer (SCLC)?
    Provided by the Springer Nature SharedIt content-sharing initiative Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by an exceptionally high proliferative rate, strong predilection for early metastasis and poor prognosis. SCLC is strongly associated with exposure to tobacco carcinogens.

    Small-cell lung cancer | Nature Reviews Disease Primers

    nature.com
    Is there a future for small-cell lung cancer?
    Thus, while the past has been bleak, the future offers greater promise. Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung cancers and is pathologically, molecularly, biologically and clinically very different from other lung cancers.

    Small-cell lung cancer: what we know, what we need to know and the p…

    nature.com
    Can breakthroughs improve small-cell lung cancer outcomes?
    Herein, authors review the breakthroughs that hold the promise to improve SCLC outcomes. In 2016, the pace of biological insights into small-cell lung cancer (SCLC) was reflected in new treatment approaches that have suggested meaningful clinical benefit to patients.

    Small cell lung cancer | Nature Reviews Clinical Oncology

    nature.com
    Why is small-cell lung cancer difficult to treat?
    Provided by the Springer Nature SharedIt content-sharing initiative Small-cell lung cancer is an aggressive form of lung cancer and has been difficult to treat due to therapy resistance. This Review discusses challenges and recent advances in uncovering molecular changes that allow potentially efficient therapies.

    Small-cell lung cancer: what we know, what we need to know and the p…

    nature.com
    Is small cell lung cancer a recalcitrant cancer?
    Small cell lung cancer (SCLC) is a recalcitrant cancer with an urgent need for novel therapeutics, preclinical models, and elucidation of the molecular pathways responsible for its rapid resistance. Recently, there have been many significant advancements in our knowledge of SCLC that led to the development of novel treatments.

    Advancements in small cell lung cancer - PubMed

    pubmed.ncbi.nlm.nih.gov
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  8. Nature
    https://www.nature.com › subjects › small-cell-lung-cancer › nrclinonc

    Small-cell lung cancer | Nature Reviews Clinical Oncology

  9. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Emerging Strategies for the Treatment of Small Cell Lung …

  10. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Real-world treatment patterns and outcomes in small-cell lung …

  11. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Small-cell lung cancer - PubMed

  12. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Update on the Biology, Management, and Treatment of Small …

  13. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Small-cell lung cancer: what we know, what we need to know and …

  14. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Treatment for small cell lung cancer, where are we now?—a review

  15. ASCO Publications
    https://ascopubs.org › doi

    Big Decisions on Small Cell Lung Cancer: A Focus on Clinical …

  16. ASCO Publications
    https://ascopubs.org › doi

    Small Cell Lung Cancer: New Hope, New Challenges

  17. Nature
    https://www.nature.com › articles

    Small cell lung cancer | Nature Reviews Disease Primers

  18. BMC Cancer
    https://bmccancer.biomedcentral.com › articles

    Preoperative immunochemotherapy versus chemotherapy as first …

  19. Annals of Oncology
    https://www.annalsofoncology.org › article › fulltext

    Small cell lung cancer: a slightly less orphan disease after ...

  20. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Small Cell Lung Carcinoma: Current Diagnosis, Biomarkers, and …

  21. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    Combined treatment of small cell lung cancer using radiotherapy …

  22. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Advancements in small cell lung cancer - PubMed

  23. Taylor & Francis Online
    https://www.tandfonline.com › doi › full

    A simplified scoring system for predicting treatment response in ...

  24. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Real-world effectiveness and tolerability of small-cell lung cancer ...

  25. Markets Insider
    https://markets.businessinsider.com › news › stocks › ...

    HUTCHMED Announces NDA Acceptance in China with Priority …

  26. Nature
    https://www.nature.com › articles

    First-line chemotherapy with tislelizumab for patients with …

  27. Nasdaq
    https://www.nasdaq.com › articles › hutchmeds-lung...

    HUTCHMED’s Lung Cancer Drug Combo Gains Priority Review

  28. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Estrogen, estrogen receptor and the tumor microenvironment of …

  29. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Small-cell lung cancer with recurrent syncope as the initial …

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