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Sep 29, 2024 · Pitolisant (Wakix), Sodium oxybate (Xyrem, Xywav,) and solriamfetol are used to treat excessive daytime sleepiness associated with narcolepsy

Apr 8, 2021 · Treatment of EDS secondary to central disorders of hypersomnolence is primarily pharmacologic with wakefulness-promoting agents such as modafinil, stimulants such as methylphenidate and amphetamines, and newer agents specifically designed to improve wakefulness; behavioral interventions can provide a useful adjunct to pharmacologic treatment.

Mar 22, 2025 · Drawing from clinical guidelines, pharmacological studies, and real-world evidence, we explore the medications used to treat narcolepsy and excessive daytime sleepiness, offering insights into how each works, who it might benefit, and what considerations need to be made in terms of side effects and lifestyle compatibility.

May 16, 2025 · Common options include modafinil and armodafinil for promoting wakefulness in narcolepsy and OSA. 2,6 Traditional stimulants like methylphenidate and amphetamine salts are also used to...

People with idiopathic hypersomnia can sleep for adequate amounts of time each night but still feel excessively sleepy during the day. They may also experience severe sleep inertia or sleep drunkenness (difficulty waking, and grogginess and disorientation upon awakening).

Oct 30, 2023 · As the disorders or causes are addressed — often using a combination of treatments — daytime sleepiness improves. When it comes to treating EDS, physicians commonly identify one or more underlying disorders and recommend treatments accordingly.

Jan 24, 2024 · Excessive daytime sleepiness (EDS) is persistent drowsiness and difficulty staying awake during the day. With excessive daytime sleepiness, you might doze off at inappropriate or unexpected...

Nuvigil (armodafinil), which is taken during the day, is approved to help with EDS in people with narcolepsy, obstructive sleep apnea, or shift work sleep disorder. How Does Nuvigil Work for...

Almost all of the currently available stimulants used to treat excessive daytime sleepiness in clinical practice (amphetamines, amphetaminelike stimulants, and modafinil) increase dopaminergic transmission either by stimulating dopamine release and/or by …

Several different types of stimulants (or wake-promoting compounds) are available to treat EDS, and a variety of new drugs are under development. The side effects of some of the stimulants are potent, and careful selection and management is required.