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  2. Epineurium
    • According to 4 sources
    Within a nerve, each axon is surrounded by a layer of connective tissue called the endoneurium. The axons are bundled together into groups called fascicles. Each fascicle is wrapped in a layer of connective tissue called the perineurium. Finally, the entire nerve is wrapped in a layer of connective tissue called the epineurium.
    It is the middle of the three connective tissue layers of peripheral nerves, with the innermost being the endoneurium surrounding individual axons, and the outermost being the epineurium surrounding the entire nerve (all nerve fascicles bundled together).
    Epineurium is composed of dense connective tissue containing collagen fibers and scattered fibroceytes. The epineurium is divided into an outer layer that surrounds the whole nerve, termed the epidascicular epineurium and an inner layer that surrounds each fascicle with concentric rings, the interfascicular epineurium.
    epineurium: outermost layer of connective tissue that surrounds an entire nerve
     
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