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DNAzyme for TGF-beta suppressed extracellular matrix ... - PubMed
Results: In cultured rat mesangial cells, treatment with TGFDE blocked TGF-beta1 mRNA expression, and thereby suppressed type I collagen mRNA expression. Next, we introduced …
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A promising nucleic acid therapy drug: DNAzymes and its …
Isaka et al. (2004) designed a specific DNAzyme (TGFDE) targeting TGF-β1 mRNA. In cultured rat mesangial cells, TGFDE effectively inhibited TGF-β1 mRNA expression, thereby blocking …
Tgfde - YouTube
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DNAzyme for TGF-β suppressed extracellular matrix …
DNAzyme for TGF-β suppressed extracellular matrix accumulation in experimental glomerulonephritis.
We generated a DNAzyme (TGFDE) targeting transforming growth factor-b1 (TGF-b1), and examined the therapeutic effect of TGFDE in vitro and in vivo. Results. In cultured rat …
B.M. EX - Appolonia - YouTube
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DNAzyme for TGF-beta suppressed extracellular matrix
Aug 1, 2004 · A DNAzyme (TGFDE) targeting transforming growth factor-beta1 (TGF-beta1) was developed and tested in vitro and in vivo. TGFDE reduced TGF-beta1, alpha-smooth muscle …
DNAzyme for TGF-?? suppressed extracelluar matrix …
Sep 1, 2004 · We generated a DNAzyme (TGFDE) targeting transforming growth factor-beta1 (TGF-beta1), and examined the therapeutic effect of TGFDE in vitro and in vivo. In cultured rat …
Interleukin18, transforming growth factor-β, and ... - ResearchGate
Oct 1, 2010 · We generated a DNAzyme (TGFDE) targeting transforming growth factor-beta1 (TGF-beta1), and examined the therapeutic effect of TGFDE in vitro and in vivo.
tgfde - YouTube
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DNAzyme for TGF-β suppressed extracellular matrix …
Aug 1, 2004 · This article reports a novel gene therapy strategy using DNAzyme (TGFDE) to inhibit TGF-β1 expression in glomerular mesangial cells. TGFDE is a catalytic DNA molecule …
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell …
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and …
Inhibition of TGF- Signaling for the Treatment of Tumor Metastasi ...
Transforming growth factor- (TGF- ) is a cytokine involved in cell proliferation, apoptosis, differentiation, angiogenesis, cell adhesion, migration, extracellular matrix deposition, wound …
Frontiers | A promising nucleic acid therapy drug: DNAzymes and …
Sep 10, 2023 · DNAzymes are single-stranded DNA molecules with catalytic function, which can target and cleave RNA in various diseases. This review discusses the development, …
Inhibition of TGF- Signaling for the Treatment of Tumor …
Transforming growth factor-β (TGF-β) is a cytokine involved in cell proliferation, apoptosis, differentiation, angiogenesis, cell adhesion, migration, extracellular matrix deposition, wound …
DNAzymes as potential therapeutic molecules. Curr Opin
May 1, 2007 · We generated a DNAzyme (TGFDE) targeting transforming growth factor-beta1 (TGF-beta1), and examined the therapeutic effect of TGFDE in vitro and in vivo.
TGFD-Project/TGFD - GitHub
We used the TGFD mining algorithm (Here) to find TGFDs for each dataset. We implement the TGFDs as follows: Pick the top 40 TGFDs for DBPedia and IMDB and top 20 TGFDs for …
(PDF) A promising nucleic acid therapy drug: DNAzymes
Sep 11, 2023 · nephrotic rats through electroporation and found that TGFDE effectively inhibited the expression of TGF- β 1, smooth muscle actin and type I collagen in nephrotic rats on the …
What is TGF Beta? + Factors that May Inhibit/Increase It
Dec 15, 2022 · Scientists suspect that TGF-beta may play a role in autoimmune diseases, food intolerance, cognitive function, wound healing, and more. Learn about its function and factors …
Role of Transforming Growth Factor β in Human Disease
May 4, 2000 · TGF-β regulates the proliferation and differentiation of cells, embryonic development, wound healing, and angiogenesis. The essential role of the TGF-β signaling …
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