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DNAzyme for TGF-beta suppressed extracellular matrix ... - PubMed
- DOI: 10.1111/j.1523-1755.2004.00777.x
- Published: 2004/8
- Keywords: We developed an electroporation-mediated ge…
- Authors: Yoshitaka Isaka
- Page Count: 5
Background: We developed an electroporation-mediated gene transfer method targeting glomerular mesangial cells. Injecting DNA solution via renal artery followed by electric pulses using tweezers-type electrodes could result in efficient transfection in mesangial cells. Therefore, this gene transfer ...A promising nucleic acid therapy drug: DNAzymes and its …
Isaka et al. (2004) designed a specific DNAzyme (TGFDE) targeting TGF-β1 mRNA. In cultured rat mesangial cells, TGFDE effectively inhibited TGF-β1 mRNA expression, thereby blocking …
DNAzyme for TGF-β suppressed extracellular matrix …
Jul 14, 2003 · We generated a DNAzyme (TGFDE) targeting transforming growth factor-β1 (TGF-β1), and examined the therapeutic effect of TGFDE in vitro and …
- Author: Yoshitaka Isaka, hiroyuki Nakamura, hiroyuki Nakamura, Masayuki Mizui, Masayuki Mizui, Yoshitsugu Ta...
- Publish Year: 2004
DNAzyme for TGF-beta suppressed extracellular matrix
Aug 1, 2004 · A DNAzyme (TGFDE) targeting transforming growth factor-beta1 (TGF-beta1) was developed and tested in vitro and in vivo. TGFDE reduced TGF-beta1, alpha-smooth muscle …
DNAzyme for TGF-?? suppressed extracelluar matrix …
Sep 1, 2004 · We generated a DNAzyme (TGFDE) targeting transforming growth factor-beta1 (TGF-beta1), and examined the therapeutic effect of TGFDE in vitro and in vivo. In cultured rat …
- Estimated Reading Time: 11 mins
Interleukin18, transforming growth factor-β, and ... - ResearchGate
Oct 1, 2010 · We generated a DNAzyme (TGFDE) targeting transforming growth factor-beta1 (TGF-beta1), and examined the therapeutic effect of TGFDE in vitro and in vivo.
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DNAzymes as potential therapeutic molecules. Curr Opin
May 1, 2007 · We generated a DNAzyme (TGFDE) targeting transforming growth factor-beta1 (TGF-beta1), and examined the therapeutic effect of TGFDE in vitro and in vivo.
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell …
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and …
Contextual Determinants of TGF-β Action in …
Recent progress has illuminated a model of TGF-β action in which SMADs bind genome-wide in partnership with lineage-determining transcription factors and additionally integrate inputs from other pathways and the chromatin to trigger …
DNAzyme for TGF-β suppressed extr... preview & related info
(2004) Isaka et al. Kidney International. Background. We developed an electroporation-mediated gene transfer method targeting glomerular mesangial cells. Injecting DNA solution via renal …
DNAzyme for TGF-β suppressed extracellular matrix …
DNAzyme for TGF-β suppressed extracellular matrix accumulation in experimental glomerulonephritis.
Transforming growth factor beta superfamily - Wikipedia
Transforming growth factor-beta (TGF-beta) [6] is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of …
Role of Transforming Growth Factor β in Human Disease
May 4, 2000 · TGF-β regulates the proliferation and differentiation of cells, embryonic development, wound healing, and angiogenesis. The essential role of the TGF-β signaling …
Faculty Profiles - KAWACHI Hiroshi - Niigata U
We generated a DNAzyme (TGFDE) targeting transforming growth factor-β1 (TGF-β1), and examined the therapeutic effect of TGFDE in vitro and in vivo. Results. In cultured rat …
Frontiers | A promising nucleic acid therapy drug: DNAzymes and …
Sep 10, 2023 · DNAzymes are single-stranded DNA molecules with catalytic function, which can target and cleave RNA in various diseases. This review discusses the development, …
DNAzyme for TGF-β suppressed extracellular matrix …
Aug 1, 2004 · This article reports a novel gene therapy strategy using DNAzyme (TGFDE) to inhibit TGF-β1 expression in glomerular mesangial cells. TGFDE is a catalytic DNA molecule …
Inhibition of TGF- Signaling for the Treatment of Tumor …
This article reviews the role of TGF-β in tumor metastasis and fibrotic diseases, and the strategies to disrupt its signaling pathway. It discusses the mechanisms of TGF-β expression, receptor …
What is TGF Beta? + Factors that May Inhibit/Increase It
Dec 15, 2022 · Scientists suspect that TGF-beta may play a role in autoimmune diseases, food intolerance, cognitive function, wound healing, and more. Learn about its function and factors …
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What is a DFDE/TFDE Vessel? - Natural Gas Intelligence
6 days ago · DFDE (Dual-Fuel Diesel Electric). TFDE (Tri-Fuel Diesel Electric). Discover how modern ships are using multiple generators to increase efficiency by burning both diesel oil …
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