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PP405 يُعتبر واحدًا من أكثر الابتكارات الطبية إثارة في مجال علاج تساقط الشعر، حيث طُوِّر في جامعة كاليفورنيا (UCLA) ويعتمد على تنشيط الخلايا الجذعية في فروة الرأس لإعادة نمو الشعر بطريقة طبيعية ...

PP405 is a promising new treatment for hair loss that activates dormant stem cells in hair follicles, potentially bypassing the effects of DHT. It is currently in phase 2 trials and could be available …

Jun 23, 2025 · The study was a randomized, multicenter, double-blind, vehicle-controlled phase 2a trial that evaluated the safety, pharmacokinetics and efficacy of PP405 for the treatment of …

6 days ago · With a focus on metabolism and stem cell biology, Pelage is advancing a new class of treatments designed to reactivate dormant hair follicle stem cells and restore the body’s …

May 31, 2025 · While exciting, the road from discovery to clinical availability is long. Researchers must conduct extensive human clinical trials to confirm PP405’s safety, efficacy, dosing, and …

Jun 17, 2025 · Typically, visible hair regrowth requires 6-12 months of continuous therapy, suggesting PP405 may yield a more rapid clinical response than current treatments, the …

Jun 17, 2025 · Yesterday, a reader e-mailed a new link on Pelage Pharmaceuticals’ Phase 2 clinical trials for its PP405 inhibitor of mitochondrial pyruvate carrier (MPC). The Phase 2 trials …

Feb 8, 2025 · It may be available in 3-6 years, with trials using a topical gel. Current treatments like finasteride, minoxidil, and derma rolling are considered the best for hair loss, while new …

Aug 13, 2024 · Study participants will receive a daily topical application of PP405 or a placebo. Participants of all skin phototypes and hair types and textures are eligible. Those interested in …

Apr 26, 2024 · Part 1 of the trial is the randomized controlled portion that will focus on safety and PK following 28 days of blinded treatment administration with either PP405 or vehicle control.

May 22, 2025 · This groundbreaking insight was published in Nature Cell Biology in 2017 and later led to the formation of Pelage Pharmaceuticals, which licensed the technology to develop …

Aug 19, 2024 · Again, this is very preliminary, only 7 days of treatment, but it's very promising as we go into the phase 2 study, from both the safety perspective, but also preliminary efficacy.