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Satellite DNA consists of abundant tandem repeats that play important roles in cellular processes, including chromosome segregation, genome organization and chromosome end protection. …

Dec 12, 2023 · In human cells, the CENP-B box is naturally present in the context of AT-rich alpha-satellite DNA 28,69 and we know that DNA sequence plays a role in DNA wrapping …

Mar 15, 2024 · We propose an antagonistic pleiotropy interpretation to reconcile centromere DNA instability as both driver of aneuploidy that underlies degenerative diseases, while also …

May 15, 2007 · Alpha-satellite DNA (AS) is part of centromeric DNA and could be relevant for centromeric chromatin structure: its repetitive character may generate a specifically ordered …

The in vitro assembly of CENP-B/alpha-satellite DNA/core histone complexes with the aid of nucleosome assembly protein-1 (NAP-1) permitted an investigation into the nucleosome …

Jan 4, 2002 · The in vitro assembly of CENP-B/α-satellite DNA/core histone complexes with the aid of nucleosome assembly protein-1 (NAP-1) permitted an investigation into the nucleosome …

Jul 7, 1983 · The results show that nucleosomes occupy eight strictly defined positions on the alpha-satellite DNA which could be determined with an accuracy of +/- 1 base pair. …

Human centromeres are composed of large tandem arrays of repetitive alpha-satellite DNA, which are often sites of aberrant rearrangements that may lead to chromosome fusions and genetic …

Aug 7, 2017 · Human centromeres are defined by alpha satellite DNA that is based on a 171-bp monomeric subunit. Individual monomers that are only 50%–70% identical are tandemly …

Sep 16, 2014 · We showed that alpha-satellite monomers could function as origins of DNA replication and that replication of alphoid arrays organized into centrochromatin occurred …

Nov 18, 2019 · The first generation of HACs co-opted alpha-satellite DNA sequences derived from natural centromere sequences [5,6]. These sequences were able to attract CENP-A …

Nov 1, 1997 · Preliminary DNA sequence analyses of randomly selected clones revealed an apparent enrichment of α-satellite DNA in CENP-A-associated DNA libraries (data not shown). …

May 27, 2015 · Nucleosome organization: All human centromeric alpha-satellites contain sequences that can form dimeric i-motif structures in vitro (see figure). These regions occur …

Jul 5, 2018 · This review will describe the genomic and epigenetic features of alpha satellite DNA, discuss recent findings of noncoding transcripts produced from distinct alpha satellite arrays, …

We also identified one BAC that contains a long insert of entirely assembled alpha satellite DNA. It originates from chromosome 1 and had been sequenced and assembled in NCBI: BX248407 …

Jul 11, 1983 · The results show that nucleosomes occupy eight strictly defined positions on the alpha-satellite DNA which could be determined with an accuracy of +/- 1 base pair. …