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FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism …
FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- Publish Year: 2020
FANCD2-FANCI surveys DNA and recognizes double- to single …
WEBDNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair …
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FANCD2-FANCI is a clamp stabilized on DNA by ... - PubMed
WEBMar 20, 2020 · FANCD2-FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- Publish Year: 2020
DNA requirement in FANCD2 deubiquitination by USP1-UAF1
WEBJun 28, 2019 · These results help establish that monoubiquitination and deubiquitination of FANCD2 occur sequentially on DNA, implicate RAD51AP1 in the FA pathway of DNA …
- Author: Fengshan Liang, Adam S. Miller, Simonne Longerich, Caroline Tang, David Maranon, Elizabeth A. Willia...
- Publish Year: 2019
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
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Mechanism, specificity, and function of FANCD2-FANCI
WEBThis E2-E3 pair specifically targets the FANCI-FANCD2 heterodimer (ID2 complex) for ubiquitination on DNA. Deubiquitination of both FANCD2 and FANCI, which is also …
FANCD2–FANCI is a clamp stabilized on DNA by …
WEBFANCD2–FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA. Ubiquitin is …
FANCD2-FANCI is a sliding DNA clamp that specifically …
WEBFeb 8, 2024 · The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair by coordinating DNA incisions around the lesion. However, D2-I is also …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation …
Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · In order to explore whether FANCI and FANCD2 ubiquitination impacts ID2‐DNA binding, we first ubiquitinated and purified human FANCI (I Ub) and FANCD2 (D2 Ub) separately using our …
WEBNov 28, 2019 · A key step in the FA DNA crosslink repair pathway is the monoubiquitination of the FANCD2-FANCI heterodimer5-9. Monoubiquitination occurs during DNA …
Structure of the FANCI-FANCD2 Complex: Insights into the
WEBJul 15, 2011 · Fanconi anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand cross-links (ICLs). Central to this pathway is the Fanconi …
FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular …
Scientists solve mystery of DNA damage detection and repair …
WEBJul 31, 2024 · The team from the MRC LMS sister institution, the LMB in Cambridge, led by Lori Passmore, had previously identified that the FANCD2-FANCI (D2-I) protein …
The key to the FANCD2–FANCI lock - Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 4, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
The Fanconi Anemia DNA Repair Pathway
WEBFanconi anemia (FA) is caused by faulty DNA repair of interstrand crosslinks (ICLs) in every cell in patients with the disease. Researchers have discovered 23 genes to date …
FANCD2 Binds CtIP and Regulates DNA-End Resection during …
WEBMay 22, 2014 · A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA …
FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding …
WEBDec 15, 2016 · In the present study, we found that the I-D complex directly binds to RAD51, and stabilizes the RAD51-DNA filament. Unexpectedly, the DNA binding activity of …
DNA clamp function of the monoubiquitinated Fanconi anaemia …
WEBMar 11, 2020 · Cryo-EM structures of the FANCI–FANCD2 complex bound to DNA reveal that monoubiquitination triggers structural changes that enable the complex to function …
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand …
WEBJul 29, 2010 · The mono-ubiquitylated ID complex locates to sites of DNA damage to which it recruits FAN1, a mono-ubiquitin–binding protein. FAN1 has a DNA …
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