The Balkan Mesolithic begins around 15,000 years ago. In Western Europe, the Early Mesolithic, or Azilian, begins about 14,000 years ago, in the Franco-Cantabrian region of northern Spain and Southern France. In other parts of Europe, the Mesolithic begins by 11,500 years ago (the beginning of the Holocene), and it ends with the introduction of farming, depending on the region between c. 8,500 and 5,500 years ago. Regions that experienced greater environmental effects as the last glacial period ended have a much more apparent Mesolithic era, lasting millennia. In northern Europe, for example, societies were able to live well on rich food supplies from the marshlands created by the warmer climate. Such conditions produced distinctive human behaviors that are preserved in the material record, such as the Maglemosian and Azilian cultures. Such conditions also delayed the coming of the Neolithic until some 5,500 BP in northern Europe.

The type of stone toolkit remains one of the most diagnostic features: the Mesolithic used a microlithic technology – composite devices manufactured with Mode V chipped stone tools (microliths), while the Paleolithic had utilized Modes I–IV. In some areas, however, such as Ireland, parts of Portugal, the Isle of Man and the Tyrrhenian Islands, a macrolithic technology was used in the Mesolithic. In the Neolithic, the microlithic technology was replaced by a macrolithic technology, with an increased use of polished stone tools such as stone axes.

There is some evidence for the beginning of construction at sites with a ritual or astronomical significance, including Stonehenge, with a short row of large post holes aligned east–west, and a possible "lunar calendar" at Warren Field in Scotland, with pits of post holes of varying sizes, thought to reflect the lunar phases. Both are dated to before c. 9,000 BP (the 8th millennium BC).

An ancient chewed gum made from the pitch of birch bark revealed that a woman enjoyed a meal of hazelnuts and duck about 5,700 years ago in southern Denmark. Mesolithic people influenced Europe's forests by bringing favored plants like hazel with them.

As the "Neolithic package" (including farming, herding, polished stone axes, timber longhouses and pottery) spread into Europe, the Mesolithic way of life was marginalized and eventually disappeared. Mesolithic adaptations such as sedentism, population size and use of plant foods are cited as evidence of the transition to agriculture. Other Mesolithic communities rejected the Neolithic package likely as a result of ideological reluctance, different worldviews and an active rejection of the sedentary-farming lifestyle. In one sample from the Blätterhöh…

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While Paleolithic and Neolithic have been found useful terms and concepts in the archaeology of China, and can be mostly regarded as happily naturalized, Mesolithic was introduced later, mostly after 1945, and does not appear to be a necessary or useful term in the context of China. Chinese sites that have been regarded as Mesolithic are better considered as "Early Neolithic".

In the archaeology of India, the Mesolithic, dated roughly between 12,000 and 8,000 BP, remains a concept in use.

In the archaeology of the Americas, an Archaic or Meso-Indian period, following the Lithic stage, somewhat equates to the Mesolithic.

The Saharan rock paintings found at Tassili n'Ajjer in central Sahara, and at other locations depict vivid scenes of everyday life in central North Africa. Some of these paintings were executed by a hunting people who lived in a savanna region teeming with a water-dependent species like the hippopotamus, animals that no longer exist in the now-desert area.

• Caucasus hunter-gatherer
• History of archery#Prehistory
• List of Stone Age art
• List of Mesolithic settlements
• Mammoth extinction
• Eastern Hunter-Gatherer
• Scandinavian Hunter-Gatherer
• Western Hunter-Gatherer
• Anatolian hunter-gatherers
• Younger Dryas