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In light of the increasing incidence for UV-induced skin cancer and the progressive depletion of the ozone layer, which contrasts to public perception of a tan as being healthy, a better understanding of the role of melanin in preventing UV-induced DNA damage and malignant …

Keywords: melanocyte, ultraviolet, phototransduction, calcium signaling, UV. Introduction. Melanocytes are neural crest derived cells that migrate during development to the skin, ear, …

Melanocytes reside within the basal epidermis of human skin, and function to protect the skin from ultraviolet light through the production of melanin. Prolonged exposure of the skin to UV light …

Exposure to visible light in ex-vivo and clinical studies demonstrated an induction of pigmentation in skin by visible light. Results showed that a single exposure to visible light induced very little …

Here, we show that visible light can damage melanocytes through melanin photosensitization and singlet oxygen (1 O 2) generation, thus decreasing cell viability, increasing membrane …

Yellow light inhibits melanogenesis and downregulates melanin content. In our former study, a dose-dependent inhibition of melanogenesis was observed, along with the induction of human …

Alpha-melanocyte-stimulating hormone (alpha-MSH) increases melanogenesis and protects from UV-induced DNA damage. However, its effect on mitochondrial DNA (mtDNA) damage is …

Melanoma is the deadliest form of skin cancer and among the malignancies of highest increasing incidence over the last several decades. Melanoma incidence is directly related to age, with …

In conclusion, our results demonstrate that human melanocytes use a novel mechanism to sense and respond to ultraviolet light, in which UVA activates endogenous opsin receptors to cause …

The molecular mechanisms used by melanocytes to detect and respond to long-wavelength UVR (UVA) are not well understood. We recently identified a UVA phototransduction pathway in …

Melanocytes are pigment-producing cells and their key regulating transcription factor is the melanocyte specific microphthalmia-associated transcription factor (m-MITF). Ultraviolet (UV) …

Besides UV-sensitive keratinocytes, other obvious candidates are melanocytes that can sense UV and respond to it through melanogenesis, synthesis, and release of neurohormones and …

Several studies showed bFGF and UV radiation have potential to induce malignant transformation of melanocytes. bFGF together with UVB radiation was able to induce in human skin …

The melanopsin system responsible for photoentrainment, was isolated from the photosensitive dermal melanophores of frogs Xenopus laevis responding to light. Melanocytes form a …

UV radiation induces immediate pigment darkening (IPD) by chemical modification of melanin, and possibly spatial redistribution of melanosomes in keratinocytes and melanocytes . UV …

Much data suggest that transformed melanocytes have higher levels of free radicals and ROS (13–16), for instance the elevation of redox-responsive signaling pathways in melanoma, e.g. …

Mainly UV-A photons, but also UV-B photons from UV radiation, which are capable of penetrating the entire epidermis, come into contact with melanin. This contact leads to melanin …

The two main types of melanin, eumelanin, and pheomelanin, are produced by melanocytes in the epidermal layer of the skin. Pheomelanin causes lighter skin tones, while eumelanin is …

Melanocytes simultaneously exposed to the drug and UV radiation had more melanin than unirradiated cells treated with minocycline. The highest melanin content was noticed in …

The mechanisms underlying blue light-induced pigmentation has been recently reported to involve the presence in the melanocyte membrane of a light photoreceptor belonging to Opsins family, …