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Replisome dynamics and use of DNA trombone loops to bypass replication blocks†,‡
- Published: 2008/11
- Authors: Nina Y. Yao, Mike O’Donnell
- DOI: 10.1039/b811097b
Replisomes are dynamic multiprotein machines capable of simultaneously replicating both strands of the DNA duplex. This review focuses on the structure and function of the E. coli replisome, many features of which generalize to other bacteria and eukaryotic cells. For example, the bacterial replisom...Models of DNA replication, notes with Definition & diagram
See more on readbiology.com“Replication scheme in which it is proposed that both DNA strands unwind and each individual strand acts as a template for the synthesis another complementary strand is called semiconservative replication. This is the most accepted scheme of DNA replication” According to this scheme integrity of each strand is preserve…- Estimated Reading Time: 7 mins
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Explain the trombone model of DNA replication. - CK-12 Foundation
The 'trombone' model is a visual metaphor used to explain the mechanism of DNA replication in a bidirectional and semi-discontinuous manner. DNA replication is a critical process during the …
The Replisome Components and the Trombone Model - JoVE
Nov 23, 2020 · Single-stranded DNA binding (SSB) proteins keep the DNA strands from reannealing. In prokaryotes, SSBs consist of a single subunit, whereas in eukaryotes, they are …
DNA Replication (Prokaryote) ELONGATION
Aug 16, 2022 · We discuss the dynamics of the replication fork. Specifically, we see what is the trombone model of elongation. What is a lagging strand, what is a leading strand, and how are they...
Cryo-EM structure of the replisome reveals multiple …
The “trombone” model of the replication fork postulates that the lagging-strand forms a loop such that the leading- and lagging-strand replication proteins contact one another. The replisome then can move in one direction along the DNA …
Lagging Steps Traced in DNA Replication - Harvard …
Jan 9, 2009 · The study provides independent proof for a venerable hypothesis known as the “trombone model,” teases out timing details that help coordinate DNA synthesis between the two strands, and suggests the presence of a third …
SnapShot: The Replisome - PMC
This four-step cycle is called the “trombone” model of replication because the DNA loop that forms in the first step resembles the slide of a trombone (Sinha et al., 1980). The replisome in …
Eukaryotic Lagging Strand DNA Replication Employs a Multi …
Mar 4, 2011 · Prokaryotic DNA replication occurs within a fork structure in which the lagging strand loops around in a proposed “trombone model” to help orient the replication enzymes for …
Dynamics of DNA replication loops reveal temporal control of …
Nov 23, 2008 · The ‘trombone model’ as proposed in ref. 3 provides an elegant model for coupling many rounds of Okazaki fragment synthesis on the lagging strand of the replication fork to the …
Replisome dynamics and use of DNA trombone loops to bypass …
Replisomes are dynamic multiprotein machines capable of simultaneously replicating both strands of the DNA duplex. This review focuses on the structure and function of the E. coli replisome, …
Trombone Model of DNA Replication || B.Sc. & M.Sc. Level
In this video lecture, we discuss the following:(1) What is trombone model of DNA replication?
Polymerase Switching in DNA Replication - Cell Press
Aug 17, 2007 · Elements of this model, known as the “trombone model,” have been confirmed in a number of systems: leading- and lagging-strand polymerases are coupled but have …
Timing, Coordination, and Rhythm: Acrobatics at the DNA …
To allow for the opposite directions of synthesis, Alberts et al. proposed the “trombone model,” in which a loop reorients the lagging-strand DNA so that its polymerase can replicate DNA in …
The Replisome Components and the Trombone Model - Concept …
Single-stranded DNA binding (SSB) proteins keep the DNA strands from reannealing. In prokaryotes, SSBs consist of a single subunit, whereas in eukaryotes, they are a …
Bit Players in the Trombone Orchestra | Science - AAAS
Mar 31, 2000 · This study proposes a model to explain how torsional stress—hypothesized to develop in the DNA as a consequence of the spiral path taken around the DNA by the …
Demonstration of the Trombone Model in the DNA Replication of …
Jan 30, 2015 · This observation is consistent with the trombone model of DNA replication, where the lagging strand of DNA takes on a form similar to the slide of a trombone. The authors say, …
The Replisome Components and the Trombone Model - JoVE
Apr 30, 2023 · Single-stranded DNA binding (SSB) proteins keep the DNA strands from reannealing. In prokaryotes, SSBs consist of a single subunit, whereas in eukaryotes, they are …
Replisome dynamics and use of DNA trombone loops to bypass …
Replisomes are dynamic multiprotein machines capable of simultaneously replicating both strands of the DNA duplex. This review focuses on the structure and function of the E. coli replisome, …
Many ways to loop DNA - PubMed
Oct 11, 2013 · The binding of DNA repair proteins, including p53 and BRCA2, has been visualized at three- and four-way junctions in DNA. The trombone model of DNA replication was directly …
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