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See all on WikipediaFANCD2 - Wikipedia
Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2 (this gene), FANCE, FANCF, FANCG, FANCI , FANCJ, FANCL, … See more
Fanconi anemia is a disorder with a recessive Mendelian pattern of inheritance characterized by chromosomal instability, hypersensitivity to DNA crosslinking agents, increased See more
Tobacco smoke suppresses the expression of FANCD2, which codes for a DNA damage "caretaker" or repair mechanism. See more
• Hejna JA, Timmers CD, Reifsteck C, Bruun DA, Lucas LW, Jakobs PM, et al. (May 2000). "Localization of the Fanconi anemia complementation group D gene to a 200-kb region on chromosome 3p25.3" See more
Humans with a FANCD deficiency display hypogonadism, male infertility, impaired spermatogenesis, and reduced female fertility. Similarly, … See more
FANCD2 has been shown to interact with:
• FANCI
• Ataxia telangiectasia mutated,
• See moreWikipedia text under CC-BY-SA license FANCA - Wikipedia
The Fanconi anaemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the same as FANCA. The members of the Fanconi anaemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. The FANCA gene encodes the protein for complementation g…
Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 10 mins
FANCE - Wikipedia
WEBFanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA cross-linking agents, increased …
- Estimated Reading Time: 6 mins
- Studies of FANCD2 wikipedia
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
WEBApr 3, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group …
The Fanconi Anemia/BRCA Pathway: FANCD2 at the …
WEBAvailable data indicate that FANCD2 is involved in cell cycle regulation and DNA repair. Our current knowledge on the functional significance of FA pathway and more specifically FANCD2 and its interacting proteins in …
FANCD2 - My Cancer Genome
WEBFanconi anemia, complementation group D2 (FANCD2) is a gene that encodes a protein that is a member of the Fanconi anemia complementation group. The protein complex …
FANCD2 modulates the mitochondrial stress response to prevent …
WEBJan 29, 2021 · We show that FANCD2, a master regulator of CFS stability, dampens the activation of the mitochondrial stress response and prevents mitochondrial dysfunction.
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FANCD2 FA complementation group D2 [ (human)] | National …
WEBThis gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci …
Differential functions of FANCI and FANCD2 …
WEBJun 8, 2020 · Our above results demonstrate separate functions for the two monoubiquitination events occurring on the ID2 complex. FANCD2 ubiquitination was found to modulate ID2‐dsDNA binding affinity, …
FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that may recruit other DNA repair factors.
FANCD2 and DNA Damage - PMC | National Center for …
WEBAug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, …
Mechanism, specificity, and function of …
WEBJun 17, 2021 · Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA-associated proteins, participate in a ...
FANCI - Wikipedia
WEBFANCI monoubiquitination is essential for repairing DNA interstrand crosslinks, and clamps the protein on DNA together with its partner protein FANCD2. The …
DNA clamp function of the monoubiquitinated Fanconi anaemia …
WEBMar 11, 2020 · Cryo-EM structures of the FANCI–FANCD2 complex bound to DNA reveal that monoubiquitination triggers structural changes that enable the complex to function …
FANCD2 and DNA Damage | PubMed
WEBAug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, …
FANCB - Wikipedia
WEBFanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased …
Mechanism, specificity, and function of FANCD2-FANCI ... | PubMed
WEBAt the center of the pathway is the monoubiquitination of two FA proteins, FANCD2 and FANCI, on two specific lysine residues. This is achieved by the combined action of the …
Ferroptosis regulator FANCD2 is associated with immune …
WEBOct 4, 2022 · FANCD2 is an essential gene involved in DNA damage repair and ferroptosis inhibition. FANCD2 has been found to induce transcription-dependent and …
Fancd2 in vivo interaction network reveals a non-canonical
WEBApr 5, 2017 · Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 …
FANCD2OS - Wikipedia
WEBFANCD2OS. Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene. [5] The name is derived from mRNA …
FANCD2 - GO Wiki | Gene Ontology
WEBApr 27, 2007 · Use the links below as well as the links to the gene information pages above to check existing GO annotation for FANCD2. GO annotation for a particular gene in a …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation …
FANCL - Wikipedia
WEBThe Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). A critical step in the pathway is the monoubiquitination …
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