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  1. The Four Stages of Prostate Cancer: What You Nee…

    Learn how doctors classify prostate cancer by stages depending on how much it has spread in the body. Find out about the factors that affect your cancer stage, such as PSA levels, Gleason score, and grade groups.

    Healthline

    Doctors classify prostate cancer by stages depending on how much it has spread in the body. Tumors may also receive a grading score based on the mutations of the cancer cells.

    Prostate cancer is the second most commonly diagnosed cancer in males, only behind skin cancer. In 2018 alone, nearly 1.3 million new cases of prostate cancer were reported worldwide.

    Prostate cancer tends to progress slowly and less aggressively than many other types of cancer. If you detect prostate cancer in the early stages, there’s a very high chance of survival. In the United States, the 5-year survival rate with prostate cancer is close to 98 percent.

    Prostate cancer can be classified into four different stages, depending on how advanced it is.

    In the first stage, the tumor is only affecting your prostate and hasn’t spread to other tissues. At stage 4, the tumor has spread to tissue beyond the prostate and possibly to distant parts of your body.

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    Cancer staging helps you and your doctor understand how advanced your cancer is and how much it has spread at the time of diagnosis. Knowing your cancer stage also helps your doctor determine the best treatment options for you and estimate your chance of survival.

    The most widely used staging system for cancer is the American Joint Committee on Cancer’s TNM system that classifies cancer from stage 1 to stage 4.

    TNM stands for:

    •Tumor: the size and extent of the tumor

    •Nodes: the number or extent of nearby lymph node involvement

    •Metastasis: whether cancer has spread to distant sites in the body

    The TNM scale is used for many types of cancer. When a doctor uses it to determine your prostate cancer stage, they’ll consider several other factors as well, including:

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    Stage 1 is the least advanced form of prostate cancer. Cancer in this stage is small and hasn’t spread past the prostate gland. It’s characterized by a PSA of less than 10 ng/mL, a grade group score of 1, and a Gleason score of 6.

    Stage 1 prostate cancer has a 5-year survival rate of nearly 100 percent.

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    In stage 2, the tumor is still confined to your prostate and hasn’t spread to lymph nodes or other parts of your body. A doctor may or may not be able to feel the tumor during a prostate exam, and it may appear on ultrasound imaging. The survival rate is still near 100 percent.

    The PSA score for stage 2 is less than 20 ng/mL.

    Stage 2 cancer is further divided into three phases depending on the grade group and Gleason scores:

    •Grade group: 1

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