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See all on WikipediaFANCD2 - Wikipedia
Fanconi anemia is a disorder with a recessive Mendelian pattern of inheritance characterized by chromosomal instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not … See more
Tobacco smoke suppresses the expression of FANCD2, which codes for a DNA damage "caretaker" or repair mechanism. See more
• Hejna JA, Timmers CD, Reifsteck C, Bruun DA, Lucas LW, Jakobs PM, et al. (May 2000). "Localization of the Fanconi anemia … See more
Humans with a FANCD deficiency display hypogonadism, male infertility, impaired spermatogenesis, and reduced female fertility. Similarly, mice deficient in FANCD2 show hypogonadism, impaired fertility and impaired gametogenesis.
In the non-mutant … See moreFANCD2 has been shown to interact with:
• FANCI
• Ataxia telangiectasia mutated,
• See moreWikipedia text under CC-BY-SA license FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- Publish Year: 2020
FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · The FANCD2–FANCI (D2–I) protein complex is central to this process as it initiates repair by coordinating DNA incisions around the lesion 1. However, D2–I is also …
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The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation …
FANCD2 and DNA Damage - PMC - National Center for …
WEBAug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, …
Mechanism, specificity, and function of FANCD2-FANCI
WEBRecent work suggests that FANCD2 ubiquitination transforms the ID2 complex into a sliding DNA clamp. Further ubiquitination on FANCI does not alter this closed-on-DNA ID2 …
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FANCD2–FANCI is a clamp stabilized on DNA by …
WEBHere, our structural and biochemical analyses of FANCD2 and FANCI allow us to propose a new model for how DNA crosslink repair is initiated (Fig. 5f): D2–I binds DNA at stalled …
Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · Our above results demonstrate separate functions for the two monoubiquitination events occurring on the ID2 complex. FANCD2 ubiquitination was found to modulate ID2‐dsDNA binding affinity, …
The Fanconi Anemia/BRCA Pathway: FANCD2 at the …
WEBAvailable data indicate that FANCD2 is involved in cell cycle regulation and DNA repair. Our current knowledge on the functional significance of FA pathway and more specifically FANCD2 and its interacting proteins in …
FANCD2 and DNA Damage - PubMed
WEBAug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, …
FANCD2 modulates the mitochondrial stress response to prevent …
WEBJan 29, 2021 · We show that FANCD2, a master regulator of CFS stability, dampens the activation of the mitochondrial stress response and prevents mitochondrial dysfunction.
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
WEBAug 6, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group …
FANCI and FANCD2 have common as well as independent …
WEBOct 20, 2017 · We suggest at least two possible explanations: (i) FANCI actively opposes FANCD2 to negatively regulate HDR or (ii) FANCD2 and FANCI work in concert during …
The key to the FANCD2–FANCI lock - Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
FANCD2 Binds MCM Proteins and Controls Replisome Function …
WEBAug 29, 2013 · We found that FANCD2 can interact directly with minichromosome maintenance (MCM) proteins. ATR signaling promoted the transient association of …
FANCD2 FA complementation group D2 [ Homo sapiens (human) ]
WEBFeb 5, 2024 · Title: FANCD2 as a novel prognostic biomarker correlated with immune and drug therapy in Hepatitis B-related hepatocellular carcinoma. FBXL12 degrades …
Fancd2 in vivo interaction network reveals a non-canonical role in ...
WEBApr 5, 2017 · Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 …
FANCD2 FA complementation group D2 [ (human)] - National …
WEBThis gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci …
Fanconi anemia proteins participate in a break-induced ... - Nature
WEBJun 10, 2021 · The FA core complex, which comprises eight FA proteins (FANCA/B/C/E/F/G/L/M) and additional associated subunits, monoubiquitinates the …
Expression of FANCD2 is associated with prognosis in patients …
WEBSep 1, 2019 · FANCD2 was significantly higher in T 1-2, stage I-II NPC tissues with a disease duration shorter than 6 months than in T 3-4, stage III-IV NPC tissues with a …
FANCD2 maintains replication fork stability during ... - Nature
WEBMay 27, 2022 · In agreement with a role of FANCD2 during replication fork restart , 5hmdC exposure also increased the frequency of collapsed forks in Fancd2 −/− cells compared …
Ferroptosis regulator FANCD2 is associated with immune …
WEBOct 4, 2022 · FANCD2 is an essential gene involved in DNA damage repair and ferroptosis inhibition. FANCD2 has been found to induce transcription-dependent and …
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